Reactome | SRY [nucleoplasm]

SRY [nucleoplasm]

Stable Identifier

R-HSA-5627706

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Sex-determining region Y protein, SRY_HUMAN

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Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by WNT (Homo sapiens)
  - TCF dependent signaling in response to WNT (Homo sapiens)
    - Deactivation of the beta-catenin transactivating complex (Homo sapiens)
      - Beta-catenin binds SOX proteins (Homo sapiens)
        
        CTNNB1:SRY,SOX2,SOX3,SOX4,SOX6,SOX7,SOX9,SOX17 [nucleoplasm] (Homo sapiens)
        
        SRY,SOX2,SOX3,SOX4,SOX6,SOX7,SOX9,SOX17 [nucleoplasm] (Homo sapiens)
        
        SRY [nucleoplasm] (Homo sapiens)
        
        SRY,SOX2,SOX3,SOX4,SOX6,SOX7,SOX9,SOX17 [nucleoplasm] (Homo sapiens)
        
        SRY [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q05066 SRY

Gene Names

SRY, TDF

Chain

chain:1-204

Reference Genes

BioGPS Gene:6736 SRY

COSMIC (genes):SRY SRY

CTD Gene:6736 SRY

dbSNP Gene:6736 SRY

ENSEMBL:ENSG00000184895 SRY

ENSEMBL_homo_sapiens_GENE:ENSG00000184895.8 SRY

HGNC:11311 SRY

KEGG Gene (Homo sapiens):6736 SRY

Monarch:6736 SRY

NCBI Gene:6736 SRY

OMIM:480000 SRY

UCSC:Q05066 SRY

Reference Transcript

RefSeq:NM_003140.2 SRY

Other Identifiers

11738437_at

17116761

207893_PM_at

207893_at

32864_at

4033460

4033461

4033462

4033463

4033464

4033465

6736

8177038

A_23_P85265

GE550734

GO:0000122

GO:0000785

GO:0000978

GO:0000981

GO:0003677

GO:0003700

GO:0005515

GO:0005516

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0006351

GO:0006355

GO:0007548

GO:0009653

GO:0010628

GO:0016607

GO:0022414

GO:0030154

GO:0030238

GO:0043226

GO:0045893

GO:0045944

GO:0048856

GO:0140110

GO:0140297

GO:2000020

HMNXSV003020293

ILMN_1748182

L10102_rna1_at

PH_hs_0000265

TC0Y000121.hg

g4507224_3p_at

Participates

as an output of

Expression of SRY in testis differentiation (Homo sapiens)

as an input of

SRY and NR5A1 (SF1) bind SOX9 gene (Homo sapiens)

as a component of

SRY:NR5A1:SOX9 gene [nucleoplasm] (Homo sapiens)

as a member of

SRY,SOX2,SOX3,SOX4,SOX6,SOX7,SOX9,SOX17 [nucleoplasm] (Homo sapiens)

Inferred To

Sox14 [nucleoplasm] (Drosophila melanogaster)

SRY [nucleoplasm] (Canis familiaris)

SRY [nucleoplasm] (Sus scrofa)

sox17b.3 [nucleoplasm] (Xenopus tropicalis)

D [nucleoplasm] (Drosophila melanogaster)

sox15 [nucleoplasm] (Xenopus tropicalis)

sox-3 [nucleoplasm] (Caenorhabditis elegans)

sem-2 [nucleoplasm] (Caenorhabditis elegans)

sox21 [nucleoplasm] (Xenopus tropicalis)

Homologues of SRY [nucleoplasm] (Caenorhabditis elegans)

Homologues of SRY [nucleoplasm] (Danio rerio)

Homologues of SRY [nucleoplasm] (Drosophila melanogaster)

Homologues of SRY [nucleoplasm] (Xenopus tropicalis)

Sox21a [nucleoplasm] (Drosophila melanogaster)

sox21b [nucleoplasm] (Danio rerio)

sox19a [nucleoplasm] (Danio rerio)

sox-4 [nucleoplasm] (Caenorhabditis elegans)

SoxN [nucleoplasm] (Drosophila melanogaster)

sox1b [nucleoplasm] (Danio rerio)

sox-2 [nucleoplasm] (Caenorhabditis elegans)

LOC116407953 [nucleoplasm] (Xenopus tropicalis)

sox1a [nucleoplasm] (Danio rerio)

sox3 [nucleoplasm] (Danio rerio)

sox3 [nucleoplasm] (Xenopus tropicalis)

Sox21b [nucleoplasm] (Drosophila melanogaster)

cas [nucleoplasm] (Danio rerio)

SOX21 [nucleoplasm] (Gallus gallus)

sox19b [nucleoplasm] (Danio rerio)

Sox15 [nucleoplasm] (Drosophila melanogaster)

sox17b.1 [nucleoplasm] (Xenopus tropicalis)

sox21a [nucleoplasm] (Danio rerio)

Cross References

RefSeq

NP_003131.1

OpenTargets

ENSG00000184895

GeneCards

Q05066

HPA

ENSG00000184895-SRY

Ensembl

ENSG00000184895, ENSP00000372547, ENST00000383070

PRO

Q05066

Pharos - Targets

Q05066

Orphanet

15558

HMDB Protein

HMDBP08587

PDB

2GZK, 1HRY, 6EDB, 7YHP, 7YHQ, 1J46, 1HRZ, 7YHO, 1J47

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15599 NHRF2			0.733	9
UniProt:P84022 SMAD3	20	Ub-SMAD3 [cytosol] (R-HSA-6782830) p-S423,S425-SMAD3 D258N [cytosol] (R-HSA-3315470) p-S423,S425-SMAD3 R268C [cytosol] (R-HSA-3315075) p-S423,S425-SMAD3 R268H [cytosol] (R-HSA-3315080) SMAD3 Q316* [cytosol] (R-HSA-9668765) SMAD3 Y384* [cytosol] (R-HSA-9668782) SMAD3 W326* [cytosol] (R-HSA-9668766) SMAD3 E246* [cytosol] (R-HSA-9668776) SMAD3 Q358* [cytosol] (R-HSA-9668772) SMAD3 Q322* [cytosol] (R-HSA-9668773) SMAD3 S425F [cytosol] (R-HSA-8944158) SMAD3 E383* [cytosol] (R-HSA-9668775) SMAD3 R368* [cytosol] (R-HSA-9668768) SMAD3 Y298* [cytosol] (R-HSA-9668769) SMAD3 S425C [cytosol] (R-HSA-3308499) p-S208-SMAD3 [cytosol] (R-HSA-9731114) SMAD3 [nucleoplasm] (R-HSA-206150) 2xADPRib-p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-2187326) Ub,p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-9773841) p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-2176471)	0.499	3

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