Reactome | TIGAR [cytosol]

TIGAR [cytosol]

Stable Identifier

R-HSA-5628829

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Fructose-2,6-bisphosphatase TIGAR, C12orf5, TP53-induced glycolysis and apoptosis regulator

Locations in the PathwayBrowser for interactor UniProt:O00291%20HIP1

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External Reference Information

External Reference

UniProt:Q9NQ88 TIGAR

Gene Names

TIGAR, C12orf5

Chain

chain:1-270

Reference Genes

BioGPS Gene:57103 TIGAR

COSMIC (genes):TIGAR TIGAR

CTD Gene:57103 TIGAR

dbSNP Gene:57103 TIGAR

ENSEMBL:ENSG00000078237 TIGAR

ENSEMBL_homo_sapiens_GENE:ENSG00000078237.7 TIGAR

HGNC:1185 TIGAR

KEGG Gene (Homo sapiens):57103 TIGAR

Monarch:57103 TIGAR

NCBI Gene:57103 TIGAR

OMIM:610775 TIGAR

UCSC:Q9NQ88 TIGAR

Reference Transcript

RefSeq:NM_020375.2 TIGAR

Other Identifiers

11719731_at

11719732_at

16747004

219099_PM_at

219099_at

3401757

3401758

3401762

3401764

3401765

3401768

3401770

3401771

3401772

3401773

3401774

3401775

3401776

3401777

3401778

3401779

3401780

3401782

3401783

3401785

3401787

3401788

50396_at

57103

7953211

A_23_P128486

A_24_P564462

A_33_P3258452

GE576725

GE61956

GE867496

GO:0000423

GO:0002931

GO:0003824

GO:0004331

GO:0005515

GO:0005634

GO:0005737

GO:0005739

GO:0005741

GO:0005829

GO:0005975

GO:0006003

GO:0006091

GO:0006096

GO:0006281

GO:0006914

GO:0006915

GO:0006974

GO:0007005

GO:0009410

GO:0010332

GO:0010659

GO:0010666

GO:0012501

GO:0016787

GO:0019661

GO:0030154

GO:0043069

GO:0043226

GO:0043456

GO:0045739

GO:0045820

GO:0048856

GO:0055086

GO:0060576

GO:0071279

GO:0071456

GO:0072593

GO:1901135

GO:1901525

GO:1902153

GO:1903301

GO:1904024

GO:1905857

GO:2000378

HMNXSV003006464

ILMN_1791792

PH_hs_0002180

TC12000061.hg

g9966848_3p_at

Participates

as an output of

TP53 stimulates TIGAR expression (Homo sapiens)

Inferred To

TIGAR [cytosol] (Bos taurus)

TIGAR [cytosol] (Canis familiaris)

TIGAR [cytosol] (Gallus gallus)

TIGAR [cytosol] (Rattus norvegicus)

TIGAR [cytosol] (Sus scrofa)

tigar [cytosol] (Xenopus tropicalis)

Tigar [cytosol] (Mus musculus)

tigara [cytosol] (Danio rerio)

Cross References

RefSeq

NP_065108.1

OpenTargets

ENSG00000078237

GeneCards

Q9NQ88

HPA

ENSG00000078237-TIGAR

Ensembl

ENST00000179259, ENSP00000179259, ENSG00000078237

PRO

Q9NQ88

Pharos - Targets

Q9NQ88

HMDB Protein

HMDBP11978

PDB

3DCY

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y371 SHLB1			0.556	3
UniProt:P13473-2 P134732			0.556	3
UniProt:O00291 HIP1	7	HIP1(1-719)insL-ALK(1059-1620) fusion [cytosol] (R-HSA-9711952) HIP1(1-1019)-ALK(1058-1620) [cytosol] (R-HSA-9711970) HIP1(1-963)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711972) HIP1(1-719)insL-p-7Y-ALK(1059-1620) fusion [cytosol] (R-HSA-9711965) HIP1(1-1019)-p-7Y-ALK(1058-1620) [cytosol] (R-HSA-9711956) HIP1(1-963)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711975) HIP1 [cytosol] (R-HSA-8868153)	0.556	3
UniProt:P55212 CASP6	5	CASP6 (1-293) [cytosol] (R-HSA-6798132) CASP6(194-293) [nucleoplasm] (R-HSA-352246) CASP6(24-179) [nucleoplasm] (R-HSA-352247) CASP6(24-179) [cytosol] (R-HSA-350313) CASP6(194-293) [cytosol] (R-HSA-266128)	0.556	3
UniProt:P52789 HK2	1	HK2 [cytosol] (R-HSA-70378)	0.524	3