Reactome | NDRG1 [cytosol]

NDRG1 [cytosol]

Stable Identifier

R-HSA-5628834

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Protein NDRG1, Differentiation-related gene 1 protein, DRG-1, CAP43, RTP, Rit42

Locations in the PathwayBrowser for interactor UniProt:O75446 SAP30

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
        
        TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Homo sapiens)
        
        TP53 stimulates NDRG1 gene expression (Homo sapiens)
        
        NDRG1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q92597 NDRG1

Gene Names

NDRG1, CAP43, DRG1, RTP

Chain

initiator methionine:, chain:2-394

Reference Genes

BioGPS Gene:10397 NDRG1

COSMIC (genes):DRG1 DRG1

COSMIC (genes):NDRG1 NDRG1

CTD Gene:10397 NDRG1

dbSNP Gene:10397 NDRG1

ENSEMBL:ENSG00000104419 NDRG1

HGNC:7679 NDRG1

KEGG:hsa:10397 NDRG1

Monarch:10397 NDRG1

NCBI Gene:10397 NDRG1

OMIM:605262 NDRG1

UCSC:Q92597 NDRG1

Reference Transcript

Participates

as an output of

TP53 stimulates NDRG1 gene expression (Homo sapiens)

Cross References

OpenTargets

ENSG00000104419

ENSEMBL

ENST00000414097, ENSG00000104419, ENST00000522476, ENST00000323851, ENSP00000319977, ENSP00000427894, ENSP00000404854

HPA

ENSG00000104419-NDRG1

GeneCards

NDRG1

PRO

Q92597

Pharos - Targets

Q92597

Orphanet

NDRG1

GlyGen

Q92597

PDB

6ZMM

HMDB Protein

HMDBP01733

Interactors (23)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.671	4
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.604	3
UniProt:P05023 ATP1A1	1	ATP1A1 [plasma membrane] (R-HSA-936850)	0.564	2
UniProt:Q96NC0 ZMAT2	1	ZMAT2 [nucleoplasm] (R-HSA-9770248)	0.556	3
UniProt:Q6PID6 TTC33			0.556	3
UniProt:Q8N488 RYBP	1	RYBP [nucleoplasm] (R-HSA-8937975)	0.556	3
UniProt:Q3SYB3 FX4L6			0.556	3
UniProt:Q9H816 DCLRE1B	1	DCLRE1B [nucleoplasm] (R-HSA-6785735)	0.556	3
UniProt:Q8IUW3 SPA2L			0.556	3
IntAct:EBI-25832170 ORF			0.556	3
IntAct:EBI-25831191 CCSB			0.556	3
UniProt:Q9Y3D2 MSRB2	1	MSRB2 [cytosol] (R-HSA-5676906)	0.556	3
UniProt:Q6ZNA4-2 Q6ZNA42			0.556	3
UniProt:Q9H204 MED28	1	MED28 [nucleoplasm] (R-HSA-6804546)	0.556	3
UniProt:O75446 SAP30	1	SAP30 [nucleoplasm] (R-HSA-351693)	0.556	3
UniProt:Q9BYZ2 LDHAL6B	1	LDHAL6B [mitochondrial matrix] (R-HSA-6807613)	0.556	3
UniProt:Q9H6J7-2 CSTPP1			0.556	3
UniProt:Q99932-2 SPAG8			0.556	3
UniProt:Q9NP50 SHCAF			0.527	2
UniProt:O95136 S1PR2	1	S1PR2 [plasma membrane] (R-HSA-419419)	0.527	2
UniProt:O00168 FXYD1	1	FXYD1 [plasma membrane] (R-HSA-2752086)	0.527	2
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) CTNNB1 [nucleoplasm] (R-HSA-3451168) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1(1-115) [cytosol] (R-HSA-202930) CTNNB1(116-376) [cytosol] (R-HSA-202950) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) CTNNB1 [plasma membrane] (R-HSA-9038440) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926) p-Y-CTNNB1 [cytosol] (R-HSA-8876940)	0.499	3
UniProt:P20338 RAB4A	5	GGC-RAB4A [cytoplasmic vesicle membrane] (R-HSA-1458526) GGC-RAB4A [cytosol] (R-HSA-8874045) RAB4A [cytosol] (R-HSA-8873709) RAB4A [early endosome membrane] (R-HSA-8871356) GGC-RAB4A [recycling endosome membrane] (R-HSA-8875666)	0.463	2

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