SESN1,2,3 bind AMPK

Stable Identifier
Reaction [binding]
Homo sapiens
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SESN1, SESN2 and possibly SESN3 are able to bind the AMPK complex and increase its catalytic activity. The exact mechanism has not been elucidated, but recent studies suggest that sestrin-bound AMPK is resistant to inactivation through AKT-induced dephosphorylation (Budanov and Karin 2008, Sanli et al. 2012, Cam et al. 2014).

Literature References
PubMed ID Title Journal Year
22363791 Sestrin2 modulates AMPK subunit expression and its response to ionizing radiation in breast cancer cells

Tsakiridis, T, Linher-Melville, K, Singh, G, Sanli, T

PLoS ONE 2012
24366874 p53/TAp63 and AKT regulate mammalian target of rapamycin complex 1 (mTORC1) signaling through two independent parallel pathways in the presence of DNA damage

Zambetti, GP, Houghton, PJ, Bid, HK, Cam, H, Xiao, L, Cam, M

J. Biol. Chem. 2014
18692468 p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling

Budanov, AV, Karin, M

Cell 2008
Orthologous Events
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