Reactome | CSNK1A1 [cilium]

CSNK1A1 [cilium]

Stable Identifier

R-HSA-5632507

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cilium

Synonyms

CK1alpha, CSNK1A1

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Locations in the PathwayBrowser for interactor UniProt:Q9H4H8 FAM83D

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External Reference Information

External Reference

UniProt:P48729 CSNK1A1

Gene Names

CSNK1A1

Chain

initiator methionine:1, chain:2-337

Reference Genes

BioGPS Gene:1452 CSNK1A1

COSMIC (genes):CSNK1A1 CSNK1A1

CTD Gene:1452 CSNK1A1

dbSNP Gene:1452 CSNK1A1

ENSEMBL:ENSG00000113712 CSNK1A1

HGNC:2451 CSNK1A1

KEGG:hsa:1452 CSNK1A1

Monarch:1452 CSNK1A1

NCBI Gene:1452 CSNK1A1

OMIM:600505 CSNK1A1

UCSC:P48729 CSNK1A1

Reference Transcript

Participates

as an input of

CSNK1A1 binds SMO dimer (Homo sapiens)

as a component of

as an output of

CSNK1A1 and ADRBK1 dissociate from p-SMO dimer (Homo sapiens)

Other forms of this molecule

CSNK1A1 [nucleoplasm]

CSNK1A1 [cytosol]

Inferred To

csnk1a1 [cilium] (Danio rerio)

csnk1a1 [cilium] (Xenopus tropicalis)

Csnk1a1 [cilium] (Mus musculus)

Csnk1a1 [cilium] (Rattus norvegicus)

CSNK1A1 [cilium] (Bos taurus)

CSNK1A1 [cilium] (Canis familiaris)

CSNK1A1 [cilium] (Gallus gallus)

CSNK1A1 [cilium] (Sus scrofa)

CkIalpha [cilium] (Drosophila melanogaster)

Cross References

RefSeq

NP_001020276.1, NP_001258670.1, NP_001883.4, NP_001258671.1

ZINC - World Drugs

KC1A_HUMAN

Guide to Pharmacology - Targets

1995

OpenTargets

ENSG00000113712

ENSEMBL

ENSP00000367074, ENST00000377843, ENST00000261798, ENSP00000499757, ENST00000657001, ENSP00000261798, ENSG00000113712

ZINC - FDA approved

KC1A_HUMAN

ZINC - Substances

KC1A_HUMAN

ZINC - Biogenic

KC1A_HUMAN

ZINC target

P48729

PRO

P48729

GlyGen

P48729

PDB

5FQD, 7WTT, 8G66, 6GZD

ZINC - Investigational

KC1A_HUMAN

GeneCards

CSNK1A1

HPA

ENSG00000113712-CSNK1A1

Pharos - Targets

P48729

ZINC - Predictions - Purchasable

KC1A_HUMAN

Interactors (45)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q6ZRV2 FA83H			0.916	14
UniProt:A6ND36 FA83G			0.902	17
UniProt:Q9H4H8 FAM83D	1	FAM83D [cytosol] (R-HSA-9852722)	0.835	8
UniProt:Q5T0W9 FAM83B	1	FAM83B [cytosol] (R-HSA-9715184)	0.796	9
UniProt:O75330 HMMR	2	HMMR [cytosol] (R-HSA-8861624) HMMR [plasma membrane] (R-HSA-2160885)	0.788	5
UniProt:O15151 MDM4	5	MDM4 [nucleoplasm] (R-HSA-349430) p-S346,S367,S403-MDM4 [nucleoplasm] (R-HSA-349441) PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm] (R-HSA-6804938) p-S403-MDM4 [nucleoplasm] (R-HSA-349461) PolyUb-MDM4 [nucleoplasm] (R-HSA-6782502)	0.758	5
UniProt:Q70CQ2 USP34	1	USP34 [cytosol] (R-HSA-2130272)	0.725	4
UniProt:Q9Y343 SNX24			0.725	4
UniProt:Q9UJF2 RASAL2	1	RASAL2 [cytosol] (R-HSA-5658224)	0.725	4
UniProt:O15027 SEC16A	1	SEC16A [cytosol] (R-HSA-5685728)	0.725	4
UniProt:Q14C86 GAPVD1	1	GAPVD1 [cytosol] (R-HSA-8871123)	0.725	4
UniProt:P55735 SEC13	4	SEC13 [cytosol] (R-HSA-203981) SEC13 [ER to Golgi transport vesicle membrane] (R-HSA-204012) SEC13 [endoplasmic reticulum membrane] (R-HSA-203994) SEC13 [lysosomal membrane] (R-HSA-9638246)	0.643	3
UniProt:Q9H3U1 UN45A			0.643	3
UniProt:Q9UK59 DBR1			0.643	3
UniProt:O15169 AXIN1	11	AXIN1 [cytosol] (R-HSA-195249) p-T481,S486,S493-AXIN1 [cytosol] (R-HSA-206040) Ub-RibC-AXIN1 [cytosol] (R-HSA-3640864) RibC-AXIN1 [cytosol] (R-HSA-3640841) ub-AXIN1 [cytosol] (R-HSA-4641133) AXIN1 P255S [cytosol] (R-HSA-5251505) AXIN1 P354L [cytosol] (R-HSA-5251511) AXIN1 W247* [cytosol] (R-HSA-5251512) AXIN1 E406* [cytosol] (R-HSA-5251500) AXIN1 Y346* [cytosol] (R-HSA-4839753) AXIN1 L396M [cytosol] (R-HSA-5251503)	0.643	4
UniProt:P48730 CSNK1D	3	CSNK1D [cytosol] (R-HSA-380315) CSNK1D [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5685717) CSNK1D [nucleoplasm] (R-HSA-421305)	0.643	3
UniProt:Q5T7W0 ZN618			0.643	3
UniProt:Q96SW2 CRBN	1	CRBN [cytosol] (R-HSA-8863300)	0.641	3
UniProt:Q9BQN1 FA83C			0.61	6
UniProt:Q13546 RIPK1	20	RIPK1 [cytosol] (R-HSA-168651) RIPK1 [endosome membrane] (R-HSA-450326) K63polyUb-RIPK1 [cytosol] (R-HSA-937021) p-S166-RIPK1 [cytosol] (R-HSA-5218872) p-S357-RIPK1 [cytosol] (R-HSA-9819116) p-S320-RIPK1 [cytosol] (R-HSA-9815498) K63,M1polyUb, p-T189-RIPK1 [cytosol] (R-HSA-9817377) polyUb-K377,K604,K634-RIPK1 [cytosol] (R-HSA-9818391) RIPK1(325-671) [cytosol] (R-HSA-5212671) RIPK1(1-324) [cytosol] (R-HSA-5212664) K63,M1polyUb-RIPK1 [cytosol] (R-HSA-9793681) K48polyUb-K571,K604,K627-RIPK1 [cytosol] (R-HSA-9796639) K63,Met1polyUb-p-S25-RIPK1 [cytosol] (R-HSA-9818793) RIPK1 [plasma membrane] (R-HSA-937073) RIPK1 D324H [cytosol] (R-HSA-9693922) RIPK1 D324V [cytosol] (R-HSA-9693927) RIPK1 D324Y [cytosol] (R-HSA-9693931) RIPK1 D324N [cytosol] (R-HSA-9693930) PolyUb-RIPK1 [cytosol] (R-HSA-6783197) K48polyUb-RIPK1 [cytosol] (R-HSA-6783308)	0.602	5
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491)	0.564	2
UniProt:Q63629 Q63629			0.544	2
UniProt:Q2M2I3 FA83E			0.537	6
UniProt:Q8NEG4 FA83F			0.537	7
UniProt:O14867 BACH1	5	BACH1 [nucleoplasm] (R-HSA-9707688) BACH1 [cytosol] (R-HSA-9708429) PolyUb-BACH1 [nucleoplasm] (R-HSA-9708486) p-Y483 BACH1 [nucleoplasm] (R-HSA-9762202) p-Y483 BACH1 [cytosol] (R-HSA-9762206)	0.527	2
UniProt:P49674 CSNK1E	2	CSNK1E [cytosol] (R-HSA-205877) CSNK1E [nucleoplasm] (R-HSA-421306)	0.527	2
UniProt:P49917 LIG4	1	LIG4 [nucleoplasm] (R-HSA-53791)	0.527	2
UniProt:Q13426 XRCC4	2	XRCC4 [nucleoplasm] (R-HSA-75911) monoSUMO1-K210-XRCC4 [nucleoplasm] (R-HSA-4568892)	0.527	2
UniProt:Q7L775 EPMIP			0.527	2
UniProt:A1A519 F170A			0.527	3
UniProt:P07900 HSP90AA1	8	HSP90AA1 [lysosomal lumen] (R-HSA-9622850) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470)	0.527	4
UniProt:Q8N752 KC1AL			0.527	2
UniProt:Q9HCK1 ZDBF2			0.527	2
UniProt:Q7Z5H3 ARHGAP22	1	ARHGAP22 [cytosol] (R-HSA-200762)	0.527	2
UniProt:Q96FJ2 DYNLL2	4	DYNLL2 [cytosol] (R-HSA-2029024) DYNLL2 [plasma membrane] (R-HSA-140527) DYNLL2 [cilium] (R-HSA-5624865) DYNLL2 [ciliary tip] (R-HSA-5625337)	0.527	2
UniProt:Q9NZQ3 NCKIPSD	1	NCKIPSD [cytosol] (R-HSA-2197671)	0.527	2
UniProt:Q00987 MDM2	11	p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) MDM2 [cytosol] (R-HSA-198644) MDM2 [nucleoplasm] (R-HSA-69486) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) MDM2 [endocytic vesicle membrane] (R-HSA-416849) MDM2 [plasma membrane] (R-HSA-416843) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472)	0.524	3
UniProt:Q9BXL7 CARD11	5	p-S559,S644,S652-CARD11 [plasma membrane] (R-HSA-1168564) CARD11 [plasma membrane] (R-HSA-2685592) p-S559,S652-CARD11 [cytosol] (R-HSA-2685625) CARD11 [cytosol] (R-HSA-202161) p-S552-CARD11 [cytosol] (R-HSA-202438)	0.499	5
UniProt:Q9UDY8 MALT1	1	MALT1 [cytosol] (R-HSA-202461)	0.499	7
UniProt:Q96A00 PPP1R14A	2	p-T38-PPP1R14A [cytosol] (R-HSA-5671764) PPP1R14A [cytosol] (R-HSA-5671761)	0.488	2
UniProt:P26583 HMGB2	1	HMGB2 [nucleoplasm] (R-HSA-266211)	0.488	2
UniProt:P18754 RCC1	2	RCC1 [chromosome] (R-HSA-9668547) RCC1 [nucleoplasm] (R-HSA-180690)	0.488	3
UniProt:P09429 HMGB1	5	HC23,45-HMGB1 [extracellular region] (R-HSA-6797422) HMGB1 [nucleoplasm] (R-HSA-266221) HMGB1 [extracellular region] (R-HSA-879382) HMGB1 [secretory granule lumen] (R-HSA-6803337) HMGB1 [ficolin-1-rich granule lumen] (R-HSA-6803291)	0.488	2
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.483	2
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.483	2