Reactome | GAS8 [cytosol]

GAS8 [cytosol]

Stable Identifier

R-HSA-5633057

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser for interactor UniProt:Q9GZV8 PRDM14

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External Reference Information

External Reference

UniProt:O95995 GAS8

Gene Names

GAS8, DRC4, GAS11

Chain

chain:1-478

Reference Genes

BioGPS Gene:2622 GAS8

COSMIC (genes):GAS8 GAS8

CTD Gene:2622 GAS8

dbSNP Gene:2622 GAS8

ENSEMBL:ENSG00000141013 GAS8

HGNC:4166 GAS8

KEGG:hsa:2622 GAS8

Monarch:2622 GAS8

NCBI Gene:2622 GAS8

OMIM:605178 GAS8

UCSC:O95995 GAS8

Reference Transcript

Other Identifiers

11747204_a_at

11754639_a_at

11754816_a_at

11760542_a_at

16822224

204921_PM_at

204921_at

2622

36479_at

3674660

3674661

3674665

3674666

3674667

3674668

3674669

3674670

3674671

3674672

3674673

3674674

3674675

3674676

3674677

3674678

3674679

3674680

3674681

3674682

3674683

3674684

3674685

3674686

7998103

A_14_P120864

A_14_P133549

A_23_P206435

A_24_P279203

A_33_P3405921

GE81030

GO:0003351

GO:0003674

GO:0005515

GO:0005576

GO:0005737

GO:0005794

GO:0005815

GO:0005829

GO:0005856

GO:0005874

GO:0005886

GO:0005929

GO:0005930

GO:0007010

GO:0007018

GO:0007368

GO:0007420

GO:0008017

GO:0008092

GO:0008104

GO:0008285

GO:0015630

GO:0022414

GO:0030317

GO:0031267

GO:0031514

GO:0035082

GO:0036064

GO:0036126

GO:0043226

GO:0045880

GO:0048856

GO:0048870

GO:0051649

GO:0060294

GO:0097729

GO:1903566

GO:1904526

HMNXSV003001835

ILMN_1783798

PH_hs_0025228

TC16000711.hg

TC16000712.hg

TC16001722.hg

TC16001723.hg

g4503916_3p_at

p25994

This entity regulates

Positively

SMO translocates to the cilium (Homo sapiens)

Inferred To

Gas8 [cytosol] (Mus musculus)

GAS8 [cytosol] (Bos taurus)

GAS8 [cytosol] (Canis familiaris)

GAS8 [cytosol] (Sus scrofa)

Cross References

OpenTargets

ENSG00000141013

ENSEMBL

ENST00000536122, ENSP00000440977, ENSP00000268699, ENST00000268699

HPA

ENSG00000141013-GAS8

PRO

O95995

Pharos - Targets

O95995

Orphanet

GAS8

PDB

8J07

Interactors (111)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q7Z3Y8 KRT27	1	KRT27 [cytosol] (R-HSA-6809587)	0.666	4
UniProt:Q15041 AR6P1			0.556	3
UniProt:Q96MF2 STAC3			0.556	3
UniProt:Q15560 TCEA2			0.556	3
UniProt:Q8TD31-3 CCHCR1			0.556	3
UniProt:Q3KQV3 ZNF792	1	ZNF792 [nucleoplasm] (R-HSA-3110242)	0.556	3
UniProt:Q96HT8 MR1L1			0.556	3
UniProt:Q8NHQ1 CEP70	1	CEP70 [cytosol] (R-HSA-380257)	0.556	3
UniProt:Q9NYW8 RBAK			0.556	3
UniProt:Q96GS4 BORC6			0.556	3
UniProt:P25791-3 LMO2			0.556	3
UniProt:Q86Z20 CC125			0.556	3
UniProt:Q15311 RALBP1	1	RALBP1 [cytosol] (R-HSA-195194)	0.556	3
UniProt:Q9UBR4-2 LHX3			0.556	3
UniProt:Q13136 PPFIA1	1	PPFIA1 [cytosol] (R-HSA-383377)	0.556	3
UniProt:Q6NUQ1 RINT1	1	RINT1 [cytosol] (R-HSA-6810991)	0.556	3
UniProt:Q9NPF5 DMAP1	1	DMAP1 [nucleoplasm] (R-HSA-212166)	0.556	3
UniProt:O60504 SORBS3	1	SORBS3 [cytosol] (R-HSA-445805)	0.556	3
UniProt:O00444 PLK4	1	PLK4 [cytosol] (R-HSA-380286)	0.556	3
UniProt:Q7Z3I7 ZN572			0.556	3
UniProt:Q9BW66 CINP			0.556	3
UniProt:Q6ZNG0 ZNF620	1	ZNF620 [nucleoplasm] (R-HSA-2127603)	0.556	3
UniProt:P53674 CRBB1			0.556	3
UniProt:Q9NSC5 HOMER3	1	HOMER3 [cytosol] (R-HSA-6794236)	0.556	3
UniProt:A8MQ03 CRTP1			0.556	3
UniProt:Q9BWG6 SCNM1			0.556	3
UniProt:O75031 HSF2B			0.556	3
UniProt:Q92622 RUBIC			0.556	3
UniProt:Q14847-2 LASP1			0.556	3
UniProt:P07992-3 ERCC1			0.556	3
UniProt:P02533 KRT14	1	KRT14 [cytosol] (R-HSA-446091)	0.556	3
UniProt:Q9BWT7 CAR10			0.556	3
UniProt:Q9HCK0 ZBT26			0.556	5
UniProt:P55040 GEM	1	GEM [plasma membrane] (R-HSA-9769962)	0.556	3
UniProt:P61024 CKS1B	1	CKS1B [nucleoplasm] (R-HSA-187533)	0.556	3
UniProt:Q3SY00 T10IP			0.556	3
UniProt:P19012 KRT15	1	KRT15 [cytosol] (R-HSA-6809589)	0.556	3
UniProt:P15622-3 ZNF250			0.556	3
IntAct:EBI-22384398 CCSB ORF ID			0.556	3
UniProt:P25800 LMO1	1	LMO1 [nucleoplasm] (R-HSA-8956514)	0.556	3
UniProt:Q8IYE0 CC146			0.556	3
UniProt:Q9Y250 LZTS1			0.556	3
UniProt:Q3B820 F161A			0.556	3
UniProt:Q2TBE0 CWF19L2	1	CWF19L2 [nucleoplasm] (R-HSA-9770846)	0.556	3
UniProt:Q8TAE8 GADD45GIP1	1	GADD45GIP1 [mitochondrial matrix] (R-HSA-5368253)	0.556	3
UniProt:Q96CN9 GCC1	1	GCC1 [cytosol] (R-HSA-6813877)	0.556	3
UniProt:Q6PI77 GASP3			0.556	3
UniProt:Q9NZD8 SPG21			0.556	3
UniProt:Q9UJV3-2 MID2			0.556	3
UniProt:O75815 BCAR3			0.556	3
UniProt:A0JP26 POTB3			0.556	3
UniProt:Q9H257-2 CARD9			0.556	3
UniProt:P08779 KRT16	1	KRT16 [cytosol] (R-HSA-201581)	0.556	3
UniProt:Q16204 CCDC6			0.556	3
UniProt:Q8N3L3 TXLNB			0.556	3
UniProt:Q9UDV6 ZNF212	1	ZNF212 [nucleoplasm] (R-HSA-1027348)	0.556	3
UniProt:Q8N684-3 CPSF7			0.556	3
UniProt:O15060 ZBT39			0.556	3
UniProt:P12757 SKIL	1	SKIL [nucleoplasm] (R-HSA-2186596)	0.556	3
UniProt:Q9NVV9 THAP1			0.556	3
UniProt:Q9NRI5-2 DISC1			0.556	3
UniProt:Q9BU76 MMTAG2	3	MMTAG2 [ficolin-1-rich granule lumen] (R-HSA-6801074) MMTAG2 [extracellular region] (R-HSA-6806452) MMTAG2 [secretory granule lumen] (R-HSA-6801073)	0.556	3
UniProt:P21580 TNFAIP3	1	TNFAIP3 [cytosol] (R-HSA-688989)	0.556	3
UniProt:Q9UEG4 ZN629			0.556	3
IntAct:EBI-16436244 CCSB ORF ID			0.556	3
UniProt:O15217 GSTA4	1	GSTA4 [cytosol] (R-HSA-159204)	0.556	3
UniProt:Q9Y2V7 COG6	2	COG6 [trans-Golgi network membrane] (R-HSA-6813872) COG6 [Golgi membrane] (R-HSA-2980958)	0.556	3
UniProt:Q12933 TRAF2	5	TRAF2 [cytosol] (R-HSA-66370) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199)	0.556	3
UniProt:Q13895 BYSL	2	BYSL [nucleoplasm] (R-HSA-6791526) BYSL [cytosol] (R-HSA-6791518)	0.556	3
UniProt:P43897 TSFM	1	TSFM [mitochondrial matrix] (R-HSA-5389837)	0.556	3
UniProt:P49639 HOXA1	1	HOXA1 [nucleoplasm] (R-HSA-5617464)	0.556	3
UniProt:Q8TDD2 SP7	1	SP7 [nucleoplasm] (R-HSA-8939843)	0.556	3
UniProt:Q99633 PRPF18	1	PRPF18 [nucleoplasm] (R-HSA-5688093)	0.556	3
UniProt:Q969R5 L3MBTL2	2	L3MBTL2 [nucleoplasm] (R-HSA-6804477) polySUMO2-K675,K700-L3MBTL2 [nucleoplasm] (R-HSA-6804480)	0.556	3
UniProt:Q9GZV8 PRDM14	1	PRDM14 [nucleoplasm] (R-HSA-1112608)	0.556	3
UniProt:O60341 KDM1A	1	KDM1A [nucleoplasm] (R-HSA-996769)	0.556	3
UniProt:Q9UER7 DAXX	13	DAXX [nucleoplasm] (R-HSA-3222068) DAXX A36Qfs108 [nucleoplasm] (R-HSA-9673105) DAXX K56 [nucleoplasm] (R-HSA-9673089) DAXX A103Sfs40 [nucleoplasm] (R-HSA-9673121) DAXX C106 [nucleoplasm] (R-HSA-9673079) DAXX E72Nfs72 [nucleoplasm] (R-HSA-9673110) DAXX E104 [nucleoplasm] (R-HSA-9673078) DAXX H26Tfs118 [nucleoplasm] (R-HSA-9673114) DAXX S138 [nucleoplasm] (R-HSA-9673081) DAXX C74* [nucleoplasm] (R-HSA-9673096) DAXX R48Vfs93 [nucleoplasm] (R-HSA-9673103) DAXX L98Vfs13 [nucleoplasm] (R-HSA-9673102) monoSUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086)	0.556	5
UniProt:P24592 IGFBP6	1	IGFBP6 [extracellular region] (R-HSA-381475)	0.556	3
UniProt:Q14192 FHL2	1	FHL2 [nucleoplasm] (R-HSA-561161)	0.556	3
UniProt:Q96JC9 EAF1	1	EAF1 [nucleoplasm] (R-HSA-8932787)	0.556	3
UniProt:Q92841 DDX17	2	monoSUMO1-K50-DDX17 [nucleoplasm] (R-HSA-3900104) DDX17 [nucleoplasm] (R-HSA-3900090)	0.556	3
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:P51959 CCNG1	1	CCNG1 [nucleoplasm] (R-HSA-6792489)	0.556	3
UniProt:Q08426 EHHADH	2	EHHADH [peroxisomal matrix] (R-HSA-400155) EHHADH [cytosol] (R-HSA-9033147)	0.556	3
UniProt:P40222 TXLNA	1	TXLNA [cytosol] (R-HSA-449124)	0.556	3
UniProt:Q9Y6D9 MAD1L1	1	MAD1L1 [cytosol] (R-HSA-141433)	0.556	3
UniProt:P07947 YES1	2	MyrG-p-Y426-YES1 [plasma membrane] (R-HSA-1810411) YES1 [cytosol] (R-HSA-373640)	0.556	3
UniProt:O14744 PRMT5	3	PRMT5 [cytosol] (R-HSA-191876) PRMT5 [nucleoplasm] (R-HSA-5205609) p-Y297,304,307-PRMT5 [nucleoplasm] (R-HSA-5211300)	0.556	3
UniProt:Q96M91 CFA53			0.556	3
UniProt:Q96CN4 EVI5L			0.556	3
UniProt:Q96T60 PNKP	1	PNKP [nucleoplasm] (R-HSA-5649651)	0.556	3
UniProt:Q96MY7 F161B			0.556	3
UniProt:Q9BYV2 TRI54			0.556	3
UniProt:O15160 POLR1C	2	POLR1C [cytosol] (R-HSA-1964454) POLR1C [nucleoplasm] (R-HSA-63498)	0.556	3
UniProt:Q8WV44 TRIM41	1	TRIM41 [cytosol] (R-HSA-5688975)	0.556	3
UniProt:O00463 TRAF5			0.556	3
UniProt:P55081 MFAP1	1	MFAP1 [nucleoplasm] (R-HSA-2396419)	0.556	3
UniProt:Q5HYN5 CT451			0.556	3
UniProt:Q8N6Y0 USBP1			0.556	3
UniProt:Q8TC71 MIEAP			0.556	3
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.556	3
UniProt:O15209 ZBT22			0.556	3
UniProt:Q8N9N8 EIF1A			0.556	3
UniProt:Q6ZUT1 NKAP1			0.556	3
UniProt:Q9BW85 YJU2	1	YJU2 [nucleoplasm] (R-HSA-9770430)	0.556	3
UniProt:Q01850 CDR2			0.556	3
UniProt:Q96PV4 PNMA5			0.556	3
UniProt:Q9UHB4 NDOR1	1	NDOR1 [cytosol] (R-HSA-2564776)	0.556	3
UniProt:Q96JM7-2 L3MBTL3			0.556	3
UniProt:Q96MH2 HEXI2			0.556	3
UniProt:Q4V328 GRAP1			0.556	3

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