TP53 binds TNFRSF10A,TNFRSF10B,TNFRSF10C,TNFRSF10D genes

Stable Identifier
R-HSA-5633414
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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TP53 binds TNFRSF10A,TNFRSF10B,TNFRSF10C,TNFRSF10D genes
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TP53 (p53) binds p53-binding sites located in the first introns of the TNFRSF10A (DR4) (Liu et al. 2004), TNFRSF10B (DR5) (Takimoto et al. 2000), TNFRSF10C (DCR1) (Ruiz de Almodovar et al. 2004) and TNFRSF10D (DCR2) (Liu et al. 2005) genes.
Literature References
PubMed ID Title Journal Year
14623878 Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) decoy receptor TRAIL-R3 is up-regulated by p53 in breast tumor cells through a mechanism involving an intronic p53-binding site

Redondo, JM, Ortiz-Ferrón, G, Ruiz de Almodóvar, C, Rodríguez, A, López-Rivas, A, Ruiz-Ruiz, C

J. Biol. Chem. 2004
15289308 p53 upregulates death receptor 4 expression through an intronic p53 binding site

Khuri, FR, Sun, SY, Yue, P, Liu, X

Cancer Res. 2004
10777207 Wild-type p53 transactivates the KILLER/DR5 gene through an intronic sequence-specific DNA-binding site

Takimoto, R, el-Deiry, WS

Oncogene 2000
16230375 Decoy receptor 2 (DcR2) is a p53 target gene and regulates chemosensitivity

Khuri, FR, Sun, SY, Yue, P, Liu, X

Cancer Res. 2005
Participants
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Output
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Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2014-10-31)
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