Reactome | SPOP [nucleoplasm]

SPOP [nucleoplasm]

Stable Identifier

R-HSA-5635035

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
26344095	SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression Varmeh, S, Liu, P, Wei, W, Beck, AH, Zhang, J, Inuzuka, H, Cheng, L, Pandolfi, PP, Gan, W, Huang, J, Sun, Y, Li, Z, Dai, X, Lunardi, A, Asara, JM	Mol. Cell	2015

External Reference Information

External Reference

UniProt:O43791 SPOP

Gene Names

SPOP

Chain

chain:1-374

Reference Genes

BioGPS Gene:8405 SPOP

COSMIC (genes):SPOP SPOP

CTD Gene:8405 SPOP

dbSNP Gene:8405 SPOP

ENSEMBL:ENSG00000121067 SPOP

ENSEMBL_homo_sapiens_GENE:ENSG00000121067.19 SPOP

HGNC:11254 SPOP

KEGG Gene (Homo sapiens):8405 SPOP

Monarch:8405 SPOP

NCBI Gene:8405 SPOP

OMIM:602650 SPOP

UCSC:O43791 SPOP

Reference Transcript

Other Identifiers

11730177_a_at

11730178_s_at

11730179_a_at

11743913_s_at

16846448

204640_PM_s_at

204640_s_at

208927_PM_at

208927_at

238923_PM_at

238923_at

3761902

3761904

3761906

3761907

3761908

3761909

3761912

3761917

3761919

3761923

3761926

3761927

3761928

3761930

3761931

3761936

3761938

3761943

3761947

3761948

39423_f_at

44052_at

8016562

80786_at

8405

A_23_P107257

A_24_P270890

GE55133

GO:0000209

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0016567

GO:0016607

GO:0030162

GO:0030163

GO:0031463

GO:0031625

GO:0036211

GO:0043161

GO:0043226

GO:0051179

GO:0098772

GO:0140678

HMNXSV003032558

Hs.129951.1.S2_3p_at

Hs.151316.0.A1_3p_at

ILMN_1795404

ILMN_2397024

PH_hs_0007623

TC17001670.hg

g4507182_3p_a_at

Participates

as a component of

Inferred To

bath-41 [nucleoplasm] (Caenorhabditis elegans)

Spop [nucleoplasm] (Mus musculus)

Spop [nucleoplasm] (Rattus norvegicus)

bath-44 [nucleoplasm] (Caenorhabditis elegans)

mel-26 [nucleoplasm] (Caenorhabditis elegans)

bath-40 [nucleoplasm] (Caenorhabditis elegans)

rdx [nucleoplasm] (Drosophila melanogaster)

Homologues of SPOP [nucleoplasm] (Caenorhabditis elegans)

Homologues of SPOP [nucleoplasm] (Dictyostelium discoideum)

spop [nucleoplasm] (Danio rerio)

spop [nucleoplasm] (Xenopus tropicalis)

spop-1 [nucleoplasm] (Caenorhabditis elegans)

SPOP [nucleoplasm] (Bos taurus)

SPOP [nucleoplasm] (Canis familiaris)

SPOP [nucleoplasm] (Dictyostelium discoideum)

SPOP [nucleoplasm] (Gallus gallus)

SPOP [nucleoplasm] (Sus scrofa)

bath-42 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

XP_005257780.1, NP_001007229.1, NP_001007227.1, NP_001007230.1, NP_001007228.1, NP_001007231.1, XP_005257781.1, XP_016880693.1, NP_003554.1

OpenTargets

ENSG00000121067

GeneCards

O43791

HPA

ENSG00000121067-SPOP

Ensembl

ENSP00000424119, ENSP00000240327, ENST00000503676, ENSP00000426986, ENST00000509079, ENST00000665825, ENSP00000420908, ENST00000504102, ENSG00000121067, ENSP00000377001, ENST00000347630, ENSP00000425905, ENST00000393328, ENST00000514121, ENSP00000499562

PRO

O43791

Pharos - Targets

O43791

PDB

7LIQ, 3HQM, 6I5P, 3HTM, 3HU6, 6I7A, 3IVV, 3IVQ, 8DWV, 4O1V, 4EOZ, 7LIN, 3HQH, 3HSV, 6I68, 8DWS, 6F8F, 7LIO, 3HQI, 4J8Z, 4HS2, 2CR2, 8DWT, 6I41, 7LIP, 6F8G, 7D3D, 7KLZ, 3HQL, 3IVB, 8DWU

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q99836 MYD88	8	MyD88 R196C [cytosol] (R-HSA-5602329) MyD88 E52del [cytosol] (R-HSA-5602451) MyD88 L93P [cytosol] (R-HSA-5602612) MyD88 S34Y [cytosol] (R-HSA-5602521) MyD88 E65del [cytosol] (R-HSA-5602598) MYD88 [endosome membrane] (R-HSA-975123) MYD88 [plasma membrane] (R-HSA-937017) MYD88 [cytosol] (R-HSA-166059)	0.837	8
UniProt:Q9UER7 DAXX	13	monoSUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086) DAXX L98Vfs13 [nucleoplasm] (R-HSA-9673102) DAXX R48Vfs93 [nucleoplasm] (R-HSA-9673103) DAXX C74* [nucleoplasm] (R-HSA-9673096) DAXX S138* [nucleoplasm] (R-HSA-9673081) DAXX H26Tfs118 [nucleoplasm] (R-HSA-9673114) DAXX E104 [nucleoplasm] (R-HSA-9673078) DAXX E72Nfs72 [nucleoplasm] (R-HSA-9673110) DAXX C106 [nucleoplasm] (R-HSA-9673079) DAXX A103Sfs40 [nucleoplasm] (R-HSA-9673121) DAXX K56 [nucleoplasm] (R-HSA-9673089) DAXX A36Qfs*108 [nucleoplasm] (R-HSA-9673105) DAXX [nucleoplasm] (R-HSA-3222068)	0.69	5
UniProt:Q9Y6Q9 NCOA3	2	NCOA3 [nucleoplasm] (R-HSA-442488) p-S857 NCOA3 [nucleoplasm] (R-HSA-5687005)	0.632	6
UniProt:P60484 PTEN	20	K48polyUb-PTEN [cytosol] (R-HSA-8874327) PolyUb-PTEN [nucleoplasm] (R-HSA-6782515) PTEN H93R [cytosol] (R-HSA-2318524) PTEN C124R [cytosol] (R-HSA-2317439) PTEN H93Y [cytosol] (R-HSA-2318520) PTEN R130G [cytosol] (R-HSA-2317339) PTEN H93D [cytosol] (R-HSA-2318550) PTEN R130L [cytosol] (R-HSA-2317430) PTEN H93A [cytosol] (R-HSA-2318544) PTEN G129E [cytosol] (R-HSA-2318509) PTEN S170N [cytosol] (R-HSA-2318408) PTEN R173P [cytosol] (R-HSA-2317480) PTEN R130Q [cytosol] (R-HSA-2317416) PTEN H93Q [cytosol] (R-HSA-2318565) PTEN G129R [cytosol] (R-HSA-2318501) PTEN H123Y [cytosol] (R-HSA-2318469) PTEN S170R [cytosol] (R-HSA-2318437) PTEN R173C [cytosol] (R-HSA-2317478) PTEN R173H [cytosol] (R-HSA-2317473) PTEN C124S [cytosol] (R-HSA-2317379)	0.611	4
UniProt:Q08273	3	RBX1 [nucleoplasm] (R-SCE-1234142) RNF7 (RBX2) [cytosol] (R-SCE-8863132) RBX1 [cytosol] (R-SCE-180582)	0.556	3
UniProt:Q9BQB4 SOST	1	SOST [extracellular region] (R-HSA-3769322)	0.527	2

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