Reactome | TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2

TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2

Stable Identifier

R-HSA-5635741

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

TNFRSF10D binds TNFRSF10A or TNFRSF10B

ReviewStatus

5/5

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TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2

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TNFRSF10D (also known as DcR2 or TRAILR4) inhibits pro-apoptotic signaling by TRAIL (TNFSF10) receptors TNFRSF10A (TRAILR1, DR4) and TNFRSF10B (TRAILR2, DR5). TNFRSF10D has a truncated death domain (DD) but has the motifs involved in oligomerization of TRAIL receptors. While it was initially thought that TNFRSF10D functions as a decoy receptor that competes with TNFRSF10A and TNFRSF10B for ligand binding (Pan et al. 1997), latest studies indicate that it prevents TRAIL signaling by forming heterodimers with TNFRSF10A and TNFRSF10B and thus preventing formation of functional homotrimeric TRAIL ligand:receptor complexes (Neumann et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
24764293	Dominant negative effects of tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptor 4 on TRAIL receptor 1 signaling by formation of heteromeric complexes Scheurich, P, Pollak, N, Hasenauer, J, Neumann, S	J. Biol. Chem.	2014
9242610	An antagonist decoy receptor and a death domain-containing receptor for TRAIL Wei, YF, Pan, G, Dixit, VM, Yu, G, Gentz, R, Ni, J	Science	1997