Reactome | Dissociation of phosphorylated PLC-gamma 1 from p-EGFRvIII mutant

Dissociation of phosphorylated PLC-gamma 1 from p-EGFRvIII mutant

Stable Identifier

R-HSA-5637800

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Dissociation of phosphorylated PLC-gamma 1 from p-EGFRvIII mutant

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Once phosphorylated, PLC-gamma 1 is expected to dissociate from phosphorylated EGFRvIII cancer mutant and induce downstream signaling in the same way it does when activated by the wild-type EGFR. However, except for the phosphorylation of PLCG1 binding site in EGFRvIII (Grandal et al. 2007), other events involved in activation of PLCG1 signaling have not been studied in cells expressing EGFRvIII.

Literature References

PubMed ID	Title	Journal	Year
17372273	EGFRvIII escapes down-regulation due to impaired internalization and sorting to lysosomes Zandi, R, Willumsen, BM, Poulsen, HS, Pedersen, MW, van Deurs, B, Grandal, MV	Carcinogenesis	2007
10579907	Phospholipase C-gamma as a signal-transducing element Ji, Q, Carpenter, G	Exp Cell Res	1999