Conversion of PIP2 to PIP3 by PI3K bound to phosphorylated EGFRvIII

Stable Identifier
R-HSA-5637801
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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The kinase activity of PI3K mediates the phosphorylation of PIP2 to form PIP3. It is assumed that EGFRvIII cancer mutant induces PI3K/AKT signaling in a manner similar to wild-type EGFR. Accordingly, activation of PI3K/AKT signaling cascade has been demonstrated in cells expressing EGFRvIII (Lammering et al. 2003, Li et al. 2004)
Literature References
PubMed ID Title Journal Year
12944901 EGFRvIII-mediated radioresistance through a strong cytoprotective response

Hewit, TH, Amorino, GP, Valerie, K, Schmidt-Ullrich, RK, Lammering, G, Dent, P, Contessa, JN

Oncogene 2003
15077177 Mutant epidermal growth factor receptor displays increased signaling through the phosphatidylinositol-3 kinase/AKT pathway and promotes radioresistance in cells of astrocytic origin

Shu, HK, Kim, IA, Chang, CM, Bernhard, EJ, Li, B, Yuan, M

Oncogene 2004
Participants
Participates
Catalyst Activity

phosphatidylinositol-4,5-bisphosphate 3-kinase activity of p-5Y-EGFRvIII:GRB2:GAB1:PI3K [plasma membrane]

Normal reaction
Functional status

Gain of function of p-5Y-EGFRvIII:GRB2:GAB1:PI3K [plasma membrane]

Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
Rhea
Authored
Reviewed
Created
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