Reactome | RAD18 [nucleoplasm]

RAD18 [nucleoplasm]

Stable Identifier

R-HSA-5643731

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

E3 ubiquitin-protein ligase RAD18, RNF73, RING finger protein 73

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9NS91 RAD18

Gene Names

RAD18, RNF73

Chain

chain:1-495

Reference Genes

BioGPS Gene:56852 RAD18

COSMIC (genes):RAD18 RAD18

CTD Gene:56852 RAD18

dbSNP Gene:56852 RAD18

ENSEMBL:ENSG00000070950 RAD18

HGNC:18278 RAD18

KEGG:hsa:56852 RAD18

Monarch:56852 RAD18

NCBI Gene:56852 RAD18

OMIM:605256 RAD18

UCSC:Q9NS91 RAD18

Reference Transcript

RefSeq:NM_020165.3 RAD18

Other Identifiers

11728257_at

11756973_a_at

16950448

223417_3p_at

223417_PM_at

223417_at

224200_PM_s_at

224200_s_at

238670_PM_at

238670_at

238748_PM_at

238748_at

2662021

2662026

2662027

2662028

2662029

2662030

2662031

2662032

2662033

2662034

2662035

2662041

2662042

2662044

2662045

2662047

2662049

2662050

2662051

2662052

2662053

2662054

2662055

2662056

2662057

2662059

2662060

2662061

56852

58202_at

59693_at

8085145

80852_at

A_23_P121222

GE82508

GO:0000403

GO:0003677

GO:0003684

GO:0003697

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0005657

GO:0005737

GO:0005813

GO:0005815

GO:0005856

GO:0006281

GO:0006301

GO:0006513

GO:0006974

GO:0016567

GO:0016604

GO:0016740

GO:0031593

GO:0031625

GO:0035861

GO:0042405

GO:0042802

GO:0043226

GO:0044877

GO:0046872

GO:0051865

GO:0051984

GO:0061630

GO:0097505

GO:0140096

HMNXSV003057176

Hs.134542.0.A1_3p_at

Hs.287323.0.A1_3p_at

ILMN_1707548

ILMN_2084391

PH_hs_0024252

TC03001146.hg

TC03002794.hg

g8895211_3p_at

g8895211_3p_s_at

g8895211_3p_x_at

g8980616_3p_a_at

g8980616_3p_x_at

Participates

as a component of

RAD18 homodimer [nucleoplasm] (Homo sapiens)

Inferred To

Ghost homologue of RAD18 [nucleoplasm] (Caenorhabditis elegans)

Ghost homologue of RAD18 [nucleoplasm] (Drosophila melanogaster)

RAD18 [nucleoplasm] (Bos taurus)

RAD18 [nucleoplasm] (Canis familiaris)

RAD18 [nucleoplasm] (Gallus gallus)

RAD18 [nucleoplasm] (Mus musculus)

RAD18 [nucleoplasm] (Plasmodium falciparum)

RAD18 [nucleoplasm] (Saccharomyces cerevisiae)

RAD18 [nucleoplasm] (Schizosaccharomyces pombe)

RAD18 [nucleoplasm] (Sus scrofa)

Rad18 [nucleoplasm] (Rattus norvegicus)

rad18 [nucleoplasm] (Danio rerio)

rad18 [nucleoplasm] (Dictyostelium discoideum)

rad18 [nucleoplasm] (Xenopus tropicalis)

Cross References

ENSEMBL

ENST00000264926, ENSP00000264926, ENSG00000070950

OpenTargets

ENSG00000070950

IntEnz

2.3.2.27

GeneCards

RAD18

HPA

ENSG00000070950-RAD18

PRO

Q9NS91

Pharos - Targets

Q9NS91

GlyGen

Q9NS91

HMDB Protein

HMDBP09297

PDB

8IR2, 9BD3, 8IR4, 2MRF, 2YBF, 5VF0, 2Y43, 2MRE

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14527 HLTF	1	HLTF [nucleoplasm] (R-HSA-8855007)	0.623	3
UniProt:Q13416 ORC2	1	ORC2 [nucleoplasm] (R-HSA-68405)	0.556	3
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:Q9BQ90 KLHDC3	1	KLHDC3 [cytosol] (R-HSA-535552)	0.527	2
UniProt:Q00978 IRF9	2	IRF9 [nucleoplasm] (R-HSA-913522) IRF9 [cytosol] (R-HSA-879183)	0.527	2
UniProt:Q9H3M7 TXNIP	2	TXNIP [cytosol] (R-HSA-1250246) TXNIP [nucleoplasm] (R-HSA-9617747)	0.527	2
UniProt:P17275 JUNB	1	JUNB [nucleoplasm] (R-HSA-2186795)	0.527	2
UniProt:P15336 ATF2	2	p-T69,T71-ATF2 [nucleoplasm] (R-HSA-450243) ATF2 [nucleoplasm] (R-HSA-450336)	0.527	2
UniProt:O75386 TULP3	1	TULP3 [cilium] (R-HSA-5610445)	0.527	2