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PNKP [nucleoplasm]
Stable Identifier
R-HSA-5649651
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Bifunctional polynucleotide phosphatase/kinase, PNK
Locations in the PathwayBrowser for interactor UniProt:O60749 SNX2
Expand all
DNA Repair (Homo sapiens)
Base Excision Repair (Homo sapiens)
Resolution of Abasic Sites (AP sites) (Homo sapiens)
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway (Homo sapiens)
LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA (Homo sapiens)
PNKP [nucleoplasm] (Homo sapiens)
LIG3:XRCC1, POLB, NEIL1,NEIL2 and PNKP dissociate from the BER site (Homo sapiens)
PNKP [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96T60 PNKP
Gene Names
PNKP
Chain
chain:1-521
Reference Genes
BioGPS Gene:11284 PNKP
COSMIC (genes):PNKP PNKP
CTD Gene:11284 PNKP
dbSNP Gene:11284 PNKP
ENSEMBL:ENSG00000039650 PNKP
ENSEMBL_homo_sapiens_GENE:ENSG00000039650.12 PNKP
HGNC:9154 PNKP
KEGG Gene (Homo sapiens):11284 PNKP
Monarch:11284 PNKP
NCBI Gene:11284 PNKP
OMIM:605610 PNKP
UCSC:Q96T60 PNKP
Reference Transcript
RefSeq:NM_007254.3 PNKP
Other Identifiers
11284
11744073_a_at
16874401
218961_PM_s_at
218961_s_at
3868126
3868127
3868129
3868131
3868133
3868135
3868137
3868138
3868139
3868140
3868141
3868142
3868144
3868146
3868148
3868149
3868152
3868156
3868157
3868158
8038458
A_33_P3402918
GE58448
GO:0000166
GO:0003677
GO:0003684
GO:0003690
GO:0003824
GO:0004519
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005694
GO:0005730
GO:0006260
GO:0006261
GO:0006281
GO:0006287
GO:0006289
GO:0006303
GO:0006974
GO:0006979
GO:0008152
GO:0009314
GO:0010836
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0016787
GO:0017076
GO:0032200
GO:0032212
GO:0035861
GO:0043226
GO:0046403
GO:0046404
GO:0051103
GO:0051734
GO:0051973
GO:1904355
GO:2001034
HMNXSV003015996
ILMN_1694111
PH_hs_0004504
TC19001727.hg
g6005835_3p_a_at
Participates
as an output of
LIG3:XRCC1, POLB, NEIL1,NEIL2 and PNKP dissociate from the BER site (Homo sapiens)
as an input of
LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA (Homo sapiens)
as a component of
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB(3'Pi)-gap-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2:POLB:LIG3:XRCC1:PNKP:SSB-gap-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:dsDNA [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB-dsDNA [nucleoplasm] (Homo sapiens)
Inferred To
Ghost homologue of PNKP [nucleoplasm]
(Xenopus tropicalis)
Pnkp [nucleoplasm]
(Rattus norvegicus)
pnkp [nucleoplasm]
(Danio rerio)
PNKP [nucleoplasm]
(Bos taurus)
PNKP [nucleoplasm]
(Canis familiaris)
PNKP [nucleoplasm]
(Dictyostelium discoideum)
PNKP [nucleoplasm]
(Mus musculus)
PNKP [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
NP_009185.2
OpenTargets
ENSG00000039650
IntEnz
2.7.1.78
GeneCards
Q96T60
HPA
ENSG00000039650-PNKP
Ensembl
ENSP00000323511
,
ENSP00000472300
,
ENST00000596014
,
ENST00000322344
,
ENSG00000039650
PRO
Q96T60
Pharos - Targets
Q96T60
Orphanet
19137
HMDB Protein
HMDBP01284
PDB
2W3O
,
2BRF
Interactors (49)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13426 XRCC4
2
monoSUMO1-K210-XRCC4 [nucleoplasm]
(R-HSA-4568892)
XRCC4 [nucleoplasm]
(R-HSA-75911)
0.942
18
UniProt:P18887 XRCC1
1
XRCC1 [nucleoplasm]
(R-HSA-67455)
0.832
8
UniProt:O94972 TRIM37
1
TRIM37 [cytosol]
(R-HSA-976049)
0.739
6
UniProt:Q15025 TNIP1
1
TNIP1 [cytosol]
(R-HSA-5690853)
0.718
6
UniProt:Q9UID6 ZN639
0.718
6
UniProt:O43829 ZBT14
0.718
6
UniProt:P49916 LIG3
1
LIG3 [nucleoplasm]
(R-HSA-53789)
0.564
3
IntAct:EBI-23221822 CCSB ORF ID
0.556
3
UniProt:P22607 FGFR3
20
FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane]
(R-HSA-8853144)
FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane]
(R-HSA-8853131)
FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane]
(R-HSA-8853152)
FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane]
(R-HSA-8853124)
FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane]
(R-HSA-8853125)
FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane]
(R-HSA-8853127)
FGFR3 K650T [plasma membrane]
(R-HSA-1614411)
FGFR3 K650N [plasma membrane]
(R-HSA-1614406)
FGFR3 K650M [plasma membrane]
(R-HSA-1614402)
FGFR3 K650Q [plasma membrane]
(R-HSA-1614410)
FGFR3 A391E [plasma membrane]
(R-HSA-1614390)
FGFR3 K650E [plasma membrane]
(R-HSA-1614400)
FGFR3 G380R [plasma membrane]
(R-HSA-1614398)
FGFR3 G382D [plasma membrane]
(R-HSA-2018740)
FGFR3 805fs*141 [plasma membrane]
(R-HSA-1614387)
FGFR3 [plasma membrane]
(R-HSA-2038357)
FGFR3 S371C [plasma membrane]
(R-HSA-1614421)
FGFR3 Y373C [plasma membrane]
(R-HSA-1614424)
FGFR3 G370C [plasma membrane]
(R-HSA-1614394)
FGFR3 R248C [plasma membrane]
(R-HSA-1614419)
0.556
3
UniProt:Q02446 SP4
0.556
3
UniProt:Q53G59 KLHL12
1
KLHL12 [cytosol]
(R-HSA-1504203)
0.556
3
UniProt:Q8WW34-2 TMEM239
0.556
3
UniProt:Q9NS64 RPRM
0.556
3
UniProt:Q8N137 CNTRB
0.556
3
UniProt:Q8WV19 SFT2A
0.556
3
UniProt:O60749 SNX2
2
SNX2 [Golgi membrane]
(R-HSA-434333)
SNX2 [cytoplasmic vesicle membrane]
(R-HSA-434216)
0.556
3
UniProt:Q9UMX0 UBQLN1
1
UBQLN1 [cytosol]
(R-HSA-8866006)
0.556
3
UniProt:Q13554-3 CAMK2B
0.556
3
UniProt:Q9NVV9 THAP1
0.556
3
UniProt:O43586 PSTPIP1
1
PSTPIP1 [cytosol]
(R-HSA-879220)
0.556
3
UniProt:Q8NCY6 MSD4
0.556
3
UniProt:P28329-3 P283293
0.556
3
UniProt:Q13422 IKZF1
0.556
3
UniProt:Q99735 MGST2
1
MGST2 [endoplasmic reticulum membrane]
(R-HSA-176058)
0.556
3
UniProt:Q9UGQ2 FLOWR
0.556
3
UniProt:Q8N9I5 FADS6
0.556
3
UniProt:Q96PV4 PNMA5
0.556
3
UniProt:Q9BWT7 CAR10
0.556
3
UniProt:O43759-2 SYNGR1
0.556
3
UniProt:Q63ZY3 KANK2
0.556
3
UniProt:Q6FHY5 Q6FHY5
0.556
3
UniProt:Q86WV7 Q86WV7
0.556
3
UniProt:Q13422-7 IKZF1
0.556
3
UniProt:Q49A88-3 CCDC14
0.556
3
UniProt:P08247 SYP
1
SYP [clathrin-sculpted glutamate transport vesicle membrane]
(R-HSA-5215991)
0.556
3
UniProt:Q92997 DVL3
4
pp-DVL3 [cytosol]
(R-HSA-3772400)
p-DVL3 [cytosol]
(R-HSA-201680)
DVL3 [cytosol]
(R-HSA-201678)
ub-DVL3 [cytosol]
(R-HSA-4652688)
0.556
3
UniProt:P23508 CRCM
0.556
3
UniProt:Q9NRD5 PICK1
2
PICK1 [plasma membrane]
(R-HSA-416989)
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
0.556
3
UniProt:Q9UMD9 COL17A1
20
GlcGalHyl-COL17A1(1-1497) [endoplasmic reticulum lumen]
(R-HSA-2173102)
GalHyl-COL17A1(1-1497) [endoplasmic reticulum lumen]
(R-HSA-2173084)
3x4Hyp-GlcGalHyl-COL17A1(1-1497) [endoplasmic reticulum lumen]
(R-HSA-2173190)
3x4Hyp-3Hyp-GalHyl-COL17A1(1-1497) [endoplasmic reticulum lumen]
(R-HSA-2173237)
3x4Hyp-GalHyl-COL17A1(1-1497) [endoplasmic reticulum lumen]
(R-HSA-2173184)
3x4Hyp-3Hyp-GlcGalHyl-COL17A1(1-1497) [endoplasmic reticulum lumen]
(R-HSA-2173264)
3x4Hyp-COL17A1(1-1497) [endoplasmic reticulum lumen]
(R-HSA-2172934)
3x4Hyp-3Hyp-COL17A1(1-1497) [endoplasmic reticulum lumen]
(R-HSA-2172989)
3x4Hyp-5Hyl-COL17A1(1-1497) [endoplasmic reticulum lumen]
(R-HSA-2173162)
3x4Hyp-3Hyp-5Hyl-COL17A1(1-1497) [endoplasmic reticulum lumen]
(R-HSA-2173230)
5Hyl-COL17A1(1-1497) [endoplasmic reticulum lumen]
(R-HSA-2173044)
3x4Hyp-GalHyl-COL17A1(?-1497) [extracellular region]
(R-HSA-2471866)
5Hyl-COL17A1(?-1497) [extracellular region]
(R-HSA-2471851)
3x4Hyp-3Hyp-COL17A1(?-1497) [extracellular region]
(R-HSA-2471867)
3x4Hyp-5Hyl-COL17A1(?-1497) [extracellular region]
(R-HSA-2471913)
3x4Hyp-3Hyp-5Hyl-COL17A1(?-1497) [extracellular region]
(R-HSA-2471897)
COL17A1(?-1497) [extracellular region]
(R-HSA-2471870)
GalHyl-COL17A1(?-1497) [extracellular region]
(R-HSA-2471903)
3x4Hyp-3Hyp-GlcGalHyl-COL17A1(?-1497) [extracellular region]
(R-HSA-2471916)
3x4Hyp-COL17A1(?-1497) [extracellular region]
(R-HSA-2471874)
0.556
3
UniProt:O95995 GAS8
1
GAS8 [cytosol]
(R-HSA-5633057)
0.556
3
UniProt:Q15633 TARBP2
2
TARBP2 [cytosol]
(R-HSA-203864)
p-TARBP2 [cytosol]
(R-HSA-9835348)
0.556
3
UniProt:Q86TI0 TBC1D1
2
TBC1D1 [cytoplasmic vesicle membrane]
(R-HSA-1454718)
p-S237-TBC1D1 [cytosol]
(R-HSA-1454673)
0.556
3
UniProt:Q8N5K1 CISD2
0.556
3
UniProt:O43761 SNG3
0.556
3
UniProt:Q96MW1 CCD43
0.527
2
UniProt:P69905 HBA1
4
CO-H+-HBA1 [cytosol]
(R-HSA-1237026)
HBA1 [cytosol]
(R-HSA-1008268)
HBA1 [endocytic vesicle lumen]
(R-HSA-2230966)
HBA1 [extracellular region]
(R-HSA-2168862)
0.527
2
UniProt:P06746 POLB
2
PolyUb-POLB [nucleoplasm]
(R-HSA-6783152)
POLB [nucleoplasm]
(R-HSA-53845)
0.527
2
UniProt:P68871 HBB
8
CO-H+-HBB [cytosol]
(R-HSA-1237013)
HBB [ficolin-1-rich granule lumen]
(R-HSA-6801015)
HBB [tertiary granule lumen]
(R-HSA-6800191)
HBB [endocytic vesicle lumen]
(R-HSA-2230936)
HBB [extracellular region]
(R-HSA-2168872)
HBB [late endosome lumen]
(R-HSA-9631108)
HBB [cytosol]
(R-HSA-1008196)
HBB [lysosomal lumen]
(R-HSA-9625193)
0.527
2
UniProt:O43524 FOXO3
11
p-S215 FOXO3 [nucleoplasm]
(R-HSA-5687010)
p-S215 FOXO3 [cytosol]
(R-HSA-5687014)
FOXO3 [cytosol]
(R-HSA-5687032)
p-S43,S173,S294,S325-FOXO3 [nucleoplasm]
(R-HSA-8870627)
p-S43,S173,S294,S325-FOXO3 [cytosol]
(R-HSA-8870560)
FOXO3(?-673) [mitochondrial matrix]
(R-HSA-9841824)
Ac-K271,K290-FOXO3(?-673) [mitochondrial matrix]
(R-HSA-9841849)
Ac-K242,K259,K271,K290,K569-FOXO3 [nucleoplasm]
(R-HSA-9620514)
p-T32,S253,S315-FOXO3 [cytosol]
(R-HSA-9614413)
p-T32,S253,S315-FOXO3 [nucleoplasm]
(R-HSA-199289)
FOXO3 [nucleoplasm]
(R-HSA-199305)
0.499
2
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