Reactome | PNKP [nucleoplasm]

PNKP [nucleoplasm]

Stable Identifier

R-HSA-5649651

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Bifunctional polynucleotide phosphatase/kinase, PNK

Locations in the PathwayBrowser for interactor UniProt:P08247 SYP

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External Reference Information

External Reference

UniProt:Q96T60 PNKP

Gene Names

PNKP

Chain

chain:1-521

Reference Genes

BioGPS Gene:11284 PNKP

COSMIC (genes):PNKP PNKP

CTD Gene:11284 PNKP

dbSNP Gene:11284 PNKP

ENSEMBL:ENSG00000039650 PNKP

HGNC:9154 PNKP

Monarch:11284 PNKP

NCBI Gene:11284 PNKP

OMIM:605610 PNKP

UCSC:Q96T60 PNKP

Reference Transcript

RefSeq:NM_007254.3 PNKP

Other Identifiers

11284

11744073_a_at

16874401

218961_PM_s_at

218961_s_at

3868120

3868121

3868122

3868123

3868124

3868126

3868127

3868128

3868129

3868130

3868131

3868132

3868133

3868134

3868135

3868136

3868137

3868138

3868139

3868140

3868141

3868142

3868143

3868144

3868145

3868146

3868147

3868148

3868149

3868150

3868151

3868152

3868153

3868154

3868155

3868156

3868157

3868158

3868159

3868184

3868185

3868186

47058_at

8038458

90031_at

A_23_P164883

A_33_P3222451

A_33_P3402918

GE58448

GO:0003677

GO:0003684

GO:0003690

GO:0003824

GO:0004519

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0006260

GO:0006261

GO:0006281

GO:0006287

GO:0006289

GO:0006303

GO:0006979

GO:0009314

GO:0010836

GO:0016020

GO:0016301

GO:0016740

GO:0016787

GO:0017076

GO:0032206

GO:0035861

GO:0043226

GO:0046403

GO:0046404

GO:0051103

GO:0051734

GO:2001034

HMNXSV003015996

HMNXSV003027506

ILMN_1694111

PH_hs_0004504

TC19001727.hg

g6005835_3p_a_at

p8411

p8412

p8414

Participates

as an output of

LIG3:XRCC1, POLB, NEIL1,NEIL2 and PNKP dissociate from the BER site (Homo sapiens)

as an input of

LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA (Homo sapiens)

as a component of

Inferred To

Ghost homologue of PNKP [nucleoplasm] (Xenopus tropicalis)

Pnkp [nucleoplasm] (Rattus norvegicus)

pnkp [nucleoplasm] (Danio rerio)

PNKP [nucleoplasm] (Bos taurus)

PNKP [nucleoplasm] (Canis familiaris)

PNKP [nucleoplasm] (Dictyostelium discoideum)

PNKP [nucleoplasm] (Mus musculus)

PNKP [nucleoplasm] (Sus scrofa)

Cross References

OpenTargets

ENSG00000039650

ENSEMBL

ENSP00000323511, ENST00000596014, ENSP00000472300, ENST00000322344

IntEnz

2.7.1.78

HPA

ENSG00000039650-PNKP

PRO

Q96T60

Pharos - Targets

Q96T60

GlyGen

Q96T60

Orphanet

PNKP

HMDB Protein

HMDBP01284

PDB

2BRF, 2W3O

Interactors (49)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13426 XRCC4	2	monoSUMO1-K210-XRCC4 [nucleoplasm] (R-HSA-4568892) XRCC4 [nucleoplasm] (R-HSA-75911)	0.942	18
UniProt:P18887 XRCC1	1	XRCC1 [nucleoplasm] (R-HSA-67455)	0.832	8
UniProt:O94972 TRIM37	1	TRIM37 [cytosol] (R-HSA-976049)	0.739	6
UniProt:Q15025 TNIP1	1	TNIP1 [cytosol] (R-HSA-5690853)	0.718	6
UniProt:Q9UID6 ZN639			0.718	6
UniProt:O43829 ZBT14			0.718	6
UniProt:P49916 LIG3	1	LIG3 [nucleoplasm] (R-HSA-53789)	0.564	3
IntAct:EBI-23221822 CCSB ORF ID			0.556	3
UniProt:P22607 FGFR3	20	FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853144) FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853131) FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853152) FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853124) FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853125) FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853127) FGFR3 K650T [plasma membrane] (R-HSA-1614411) FGFR3 K650N [plasma membrane] (R-HSA-1614406) FGFR3 K650M [plasma membrane] (R-HSA-1614402) FGFR3 K650Q [plasma membrane] (R-HSA-1614410) FGFR3 A391E [plasma membrane] (R-HSA-1614390) FGFR3 K650E [plasma membrane] (R-HSA-1614400) FGFR3 G380R [plasma membrane] (R-HSA-1614398) FGFR3 G382D [plasma membrane] (R-HSA-2018740) FGFR3 805fs*141 [plasma membrane] (R-HSA-1614387) p-6Y-FGFR3 A391E [plasma membrane] (R-HSA-2065835) p-6Y-FGFR3 K650T [plasma membrane] (R-HSA-2032966) p-6Y-FGFR3 G382D [plasma membrane] (R-HSA-2032950) p-6Y-FGFR3 G380R [plasma membrane] (R-HSA-2032946) p-6Y-FGFR3 K650M [plasma membrane] (R-HSA-2032959)	0.556	3
UniProt:Q15633 TARBP2	2	p-TARBP2 [cytosol] (R-HSA-9835348) TARBP2 [cytosol] (R-HSA-203864)	0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	3
UniProt:O95995 GAS8	1	GAS8 [cytosol] (R-HSA-5633057)	0.556	3
UniProt:Q8N5K1 CISD2			0.556	3
UniProt:O43761 SNG3			0.556	3
UniProt:P23508 CRCM			0.556	3
UniProt:Q92997 DVL3	4	pp-DVL3 [cytosol] (R-HSA-3772400) p-DVL3 [cytosol] (R-HSA-201680) DVL3 [cytosol] (R-HSA-201678) ub-DVL3 [cytosol] (R-HSA-4652688)	0.556	3
UniProt:P08247 SYP	1	SYP [clathrin-sculpted glutamate transport vesicle membrane] (R-HSA-5215991)	0.556	3
UniProt:Q49A88-3 CCDC14			0.556	3
UniProt:Q13422-7 IKZF1			0.556	3
UniProt:Q86WV7 Q86WV7			0.556	3
UniProt:Q6FHY5 Q6FHY5			0.556	3
UniProt:Q63ZY3 KANK2			0.556	3
UniProt:O43759-2 SYNGR1			0.556	3
UniProt:Q9BWT7 CAR10			0.556	3
UniProt:Q86TI0 TBC1D1	2	TBC1D1 [cytoplasmic vesicle membrane] (R-HSA-1454718) p-S237-TBC1D1 [cytosol] (R-HSA-1454673)	0.556	3
UniProt:Q96PV4 PNMA5			0.556	3
UniProt:Q8N9I5 FADS6			0.556	3
UniProt:Q9UGQ2 FLOWR			0.556	3
UniProt:Q99735 MGST2	1	MGST2 [endoplasmic reticulum membrane] (R-HSA-176058)	0.556	3
UniProt:Q9UMD9 COL17A1	20	GlcGalHyl-COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2173102) GalHyl-COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2173084) 3x4Hyp-GlcGalHyl-COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2173190) 3x4Hyp-3Hyp-GalHyl-COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2173237) 3x4Hyp-GalHyl-COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2173184) 3x4Hyp-3Hyp-GlcGalHyl-COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2173264) 3x4Hyp-COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2172934) 3x4Hyp-3Hyp-COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2172989) COL17A1(1-1497) [plasma membrane] (R-HSA-445994) COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2172232) GlcGalHyl-COL17A1(1-1497) [plasma membrane] (R-HSA-2192833) GalHyl-COL17A1(1-1497) [plasma membrane] (R-HSA-2192832) 3x4Hyp-GalHyl-COL17A1(1-1497) [plasma membrane] (R-HSA-2192834) 3x4Hyp-3Hyp-GlcGalHyl-COL17A1(1-1497) [plasma membrane] (R-HSA-2192837) 3x4Hyp-COL17A1(1-1497) [plasma membrane] (R-HSA-2192836) 3x4Hyp-3Hyp-5Hyl-COL17A1(1-1497) [plasma membrane] (R-HSA-2192839) 3x4Hyp-5Hyl-COL17A1(1-1497) [plasma membrane] (R-HSA-2192841) 3x4Hyp-GlcGalHyl-COL17A1(1-1497) [plasma membrane] (R-HSA-2192840) 3x4Hyp-3Hyp-COL17A1(1-1497) [plasma membrane] (R-HSA-2192843) 5Hyl-COL17A1(1-1497) [plasma membrane] (R-HSA-2192842)	0.556	3
UniProt:Q13422 IKZF1			0.556	3
UniProt:P28329-3 P283293			0.556	3
UniProt:Q8NCY6 MSD4			0.556	3
UniProt:O43586 PSTPIP1	1	PSTPIP1 [cytosol] (R-HSA-879220)	0.556	3
UniProt:Q9NVV9 THAP1			0.556	3
UniProt:Q13554-3 CAMK2B			0.556	3
UniProt:Q9UMX0 UBQLN1	1	UBQLN1 [cytosol] (R-HSA-8866006)	0.556	3
UniProt:O60749 SNX2	2	SNX2 [Golgi membrane] (R-HSA-434333) SNX2 [cytoplasmic vesicle membrane] (R-HSA-434216)	0.556	3
UniProt:Q8WV19 SFT2A			0.556	3
UniProt:Q8N137 CNTRB			0.556	3
UniProt:Q9NS64 RPRM			0.556	3
UniProt:Q8WW34-2 TMEM239			0.556	3
UniProt:Q53G59 KLHL12	1	KLHL12 [cytosol] (R-HSA-1504203)	0.556	3
UniProt:Q02446 SP4			0.556	3
UniProt:Q96MW1 CCD43			0.527	2
UniProt:P68871 HBB	8	HBB [lysosomal lumen] (R-HSA-9625193) HBB [cytosol] (R-HSA-1008196) HBB [late endosome lumen] (R-HSA-9631108) HBB [tertiary granule lumen] (R-HSA-6800191) HBB [extracellular region] (R-HSA-2168872) HBB [ficolin-1-rich granule lumen] (R-HSA-6801015) HBB [endocytic vesicle lumen] (R-HSA-2230936) CO-H+-HBB [cytosol] (R-HSA-1237013)	0.527	2
UniProt:P69905 HBA1	4	HBA1 [extracellular region] (R-HSA-2168862) HBA1 [endocytic vesicle lumen] (R-HSA-2230966) HBA1 [cytosol] (R-HSA-1008268) CO-H+-HBA1 [cytosol] (R-HSA-1237026)	0.527	2
UniProt:P06746 POLB	2	POLB [nucleoplasm] (R-HSA-53845) PolyUb-POLB [nucleoplasm] (R-HSA-6783152)	0.527	2
UniProt:O43524 FOXO3	11	FOXO3 [nucleoplasm] (R-HSA-199305) p-T32,S253,S315-FOXO3 [nucleoplasm] (R-HSA-199289) p-T32,S253,S315-FOXO3 [cytosol] (R-HSA-9614413) Ac-K242,K259,K271,K290,K569-FOXO3 [nucleoplasm] (R-HSA-9620514) Ac-K271,K290-FOXO3(?-673) [mitochondrial matrix] (R-HSA-9841849) FOXO3(?-673) [mitochondrial matrix] (R-HSA-9841824) p-S43,S173,S294,S325-FOXO3 [cytosol] (R-HSA-8870560) p-S43,S173,S294,S325-FOXO3 [nucleoplasm] (R-HSA-8870627) FOXO3 [cytosol] (R-HSA-5687032) p-S215 FOXO3 [cytosol] (R-HSA-5687014) p-S215 FOXO3 [nucleoplasm] (R-HSA-5687010)	0.499	2

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