DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79)

Stable Identifier
R-HSA-5649801
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
DOT1L methylates lysine-80 of histone H3
ReviewStatus
5/5
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DOT1L is capable of catalyzing mono-, di-, and trimethylation in a nonprocessive manner (Min et al. 2003, Frederiks et al. 2008). It appear to be solely responsible for H3K79 methylation, since knockout of Dot1 in yeast, flies and mice results in complete loss of H3K79 methylation (van Leeuwen et al. 2002, Shanower et al. 2005, Jones et al. 2008).
Literature References
PubMed ID Title Journal Year
12123582 Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain

Ng, HH, Zhang, Y, Wang, H, Feng, Q, Struhl, K, Tempst, P, Erdjument-Bromage, H

Curr. Biol. 2002
Participants
Participates
Catalyst Activity

histone H3 methyltransferase activity of DOT1L [nucleoplasm]

Orthologous Events
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