WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27)

Stable Identifier
R-HSA-5649802
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
WHSC1L1 (KMT3F) methylates Me2K28-histone H3 (H3K27), WHSC1L1 methylates Me2K28-histone H3
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WHSC1 (MMSET, KMT3G) is able to mono-, di- and trimethylate lysine-28 (Kim et al. 2008). WHSC1L1 (KMT3F, WHISTLE) can di- and tri-methylate lysine-28 of histone H3 (H3K27) if it has been previously methylated at this residue (Kim et al. 2006).

Literature References
PubMed ID Title Journal Year
16682010 Characterization of a novel WHSC1-associated SET domain protein with H3K4 and H3K27 methyltransferase activity

Kim, SM, Kee, HJ, Eom, GH, Choe, NW, Kim, JY, Kim, YS, Kim, SK, Kook, H, Kook, H, Seo, SB

Biochem. Biophys. Res. Commun. 2006
18172012 Multiple-myeloma-related WHSC1/MMSET isoform RE-IIBP is a histone methyltransferase with transcriptional repression activity

Kim, JY, Kee, HJ, Choe, NW, Kim, SM, Eom, GH, Baek, HJ, Kook, H, Kook, H, Seo, SB

Mol. Cell. Biol. 2008
Participants
Participates
Catalyst Activity

histone-lysine N-methyltransferase activity of WHSC1, WHSC1L1 [nucleoplasm]

Orthologous Events
Authored
Reviewed
Created
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