Reactome | Oxidative damage to the AP site

Oxidative damage to the AP site

Stable Identifier

R-HSA-5649856

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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The APEX1-bound AP (apurinic/apyrimidinic) 5'-deoxyribose phosphate at the single strand break (SSB) is susceptible to oxidative damage, and can be converted to tetrahydrofuran-like 1,2-dideoxyribose phosphate during base excision repair (BER) (Matsumoto et al. 1994, Klungland and Lindahl 1997).

Literature References

PubMed ID	Title	Journal	Year
7915006	Proliferating cell nuclear antigen-dependent abasic site repair in Xenopus laevis oocytes: an alternative pathway of base excision DNA repair Matsumoto, Y, Bogenhagen, DF, Kim, K	Mol. Cell. Biol.	1994
9214649	Second pathway for completion of human DNA base excision-repair: reconstitution with purified proteins and requirement for DNase IV (FEN1). Lindahl, T, Klungland, A	EMBO J	1997