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PAR-PARP1,PAR-PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm]
Stable Identifier
R-HSA-5651725
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
Base Excision Repair (Homo sapiens)
Resolution of Abasic Sites (AP sites) (Homo sapiens)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Homo sapiens)
POLB-Dependent Long Patch Base Excision Repair (Homo sapiens)
PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB (Homo sapiens)
PAR-PARP1,PAR-PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Homo sapiens)
PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Homo sapiens)
PAR-PARP1,PAR-PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
11440997
DNA polymerase beta -mediated long patch base excision repair. Poly(ADP-ribose)polymerase-1 stimulates strand displacement DNA synthesis
Vande Berg, BJ
,
Wilson, SH
,
Kim, SJ
,
Kedar, P
,
Yang, XP
,
Lavrik, OI
,
Prasad, R
J. Biol. Chem.
2001
Participants
components
FEN1 [nucleoplasm]
(Homo sapiens)
PAR-PARP1,PAR-PARP2 dimers [nucleoplasm]
(Homo sapiens)
POLB [nucleoplasm]
(Homo sapiens)
SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm]
(Homo sapiens)
Participates
as an output of
PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Homo sapiens)
as an input of
PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB (Homo sapiens)
Inferred To
PAR-PARP1,PAR-PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm]
(Bos taurus)
PAR-PARP1,PAR-PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm]
(Canis familiaris)
PAR-PARP1,PAR-PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm]
(Danio rerio)
PAR-PARP1,PAR-PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm]
(Dictyostelium discoideum)
PAR-PARP1,PAR-PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm]
(Mus musculus)
PAR-PARP1,PAR-PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm]
(Rattus norvegicus)
PAR-PARP1,PAR-PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm]
(Sus scrofa)
PAR-PARP1,PAR-PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm]
(Xenopus tropicalis)
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