Reactome | LIG1 binds POLB at long-patch BER site

LIG1 binds POLB at long-patch BER site

Stable Identifier

R-HSA-5651773

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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DNA ligase I (LIG1) binds DNA polymerase beta (POLB) at the long-patch base excision repair (BER) site. LIG1 and POLB interact through their N-terminal domains (Prasad et al. 1996, Dimitriadis et al. 1998, Tomkinson et al. 2001, Ranalli et al. 2002, Balakrishnan et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
11554294	Completion of base excision repair by mammalian DNA ligases Tomkinson, AE, Motycka, TA, Mackey, ZB, Levin, DS, Leppard, JB, Chen, L, Dong, Z	Prog. Nucleic Acid Res. Mol. Biol.	2001
12200445	AP endonuclease 1 coordinates flap endonuclease 1 and DNA ligase I activity in long patch base excision repair. Ranalli, TA, Bambara, RA, Tom, S	J Biol Chem	2002
19329425	Long patch base excision repair proceeds via coordinated stimulation of the multienzyme DNA repair complex Lindsey-Boltz, LA, Sancar, A, Brandt, PD, Bambara, RA, Balakrishnan, L	J. Biol. Chem.	2009
9685411	Thermodynamics of human DNA ligase I trimerization and association with DNA polymerase beta Tomkinson, AE, Wilson, SH, Lewis, MS, Vaske, MK, Chen, L, Prasad, R, Dimitriadis, EK	J. Biol. Chem.	1998
8663274	Specific interaction of DNA polymerase beta and DNA ligase I in a multiprotein base excision repair complex from bovine testis Tomkinson, AE, Singhal, RK, Wilson, SH, Molina, JT, Srivastava, DK, Prasad, R	J. Biol. Chem.	1996