Reactome | LIG1 bound to POLB ligates SSB

LIG1 bound to POLB ligates SSB

Stable Identifier

R-HSA-5651789

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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LIG1 (DNA ligase I), recruited to the long-patch base excision repair site through its interaction with POLB, ligates the 3' end of the single strand break (SSB), containing the newly synthesized multiple nucleotide repair patch, with the FEN1-processed 5' end of the SSB, thus completing the base excision repair (Prigent et al. 1994, Tomkinson et al. 2001, Ranalli et al. 2002, Balakrishnan et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
8264597	Aberrant DNA repair and DNA replication due to an inherited enzymatic defect in human DNA ligase I Prigent, C, Satoh, MS, Daly, G, Barnes, DE, Lindahl, T	Mol. Cell. Biol.	1994
11554294	Completion of base excision repair by mammalian DNA ligases Tomkinson, AE, Chen, L, Dong, Z, Leppard, JB, Levin, DS, Mackey, ZB, Motycka, TA	Prog. Nucleic Acid Res. Mol. Biol.	2001
12200445	AP endonuclease 1 coordinates flap endonuclease 1 and DNA ligase I activity in long patch base excision repair. Ranalli, TA, Tom, S, Bambara, RA	J Biol Chem	2002
19329425	Long patch base excision repair proceeds via coordinated stimulation of the multienzyme DNA repair complex Balakrishnan, L, Brandt, PD, Lindsey-Boltz, LA, Sancar, A, Bambara, RA	J. Biol. Chem.	2009