Damaged dsDNA becomes damaged DNA template

Stable Identifier
R-HSA-5652137
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Damaged dsDNA becomes damaged DNA template
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If a damaged double strand DNA (dsDNA) is not repaired prior to the next round of DNA replication, it provides a damaged (lesioned) DNA template that triggers mutagenic (erroneous) incorporation of nucleotides in the newly synthesized DNA strand through the process of DNA damage bypass (Friedberg et al. 2001).
Literature References
PubMed ID Title Journal Year
11595180 Error-prone DNA polymerases: novel structures and the benefits of infidelity.

Kisker, C, Friedberg, EC, Fischhaber, PL

Cell 2001
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Authored
Orlic-Milacic, M  (2014-12-11)
Reviewed
Borowiec, JA  (2015-01-07)
Created
Orlic-Milacic, M  (2014-11-28)
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