Reactome | Fructose biosynthesis

Fructose biosynthesis

Stable Identifier

R-HSA-5652227

DOI

10.3180/R-HSA-5652227.4

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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The conversion of glucose to fructose via sorbitol was demonstrated by Hers (1960) in the seminal vesicles of sheep, has since been demonstrated as well in human epidydimal tissue (Frenette et al. 2006), and appears to be the physiological source of the abundant fructose found in seminal fluid. The enzymes of the pathway are likewise abundant in the eye lens and in neurons, where their physiological role is less clear but where they appear to play a central role in diabetic tissue damage (Oates 2008).

Literature References

PubMed ID	Title	Journal	Year
18220710	Aldose reductase, still a compelling target for diabetic neuropathy Oates, PJ	Curr Drug Targets	2008
14401391	[The mechanism of the formation of seminal fructose and fetal fructose] Hers, HG	Biochim. Biophys. Acta	1960
16278369	Polyol pathway in human epididymis and semen Sullivan, R, Thabet, M, Frenette, G	J. Androl.	2006