Reactome | TRIM25 [nucleoplasm]

TRIM25 [nucleoplasm]

Stable Identifier

R-HSA-5653667

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

E3 ubiquitin/ISG15 ligase TRIM25, TRI25_HUMAN, EFP

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q14258 TRIM25

Gene Names

TRIM25, EFP, RNF147, ZNF147

Chain

chain:1-630

Reference Genes

BioGPS Gene:7706 TRIM25

COSMIC (genes):TRIM25 TRIM25

CTD Gene:7706 TRIM25

dbSNP Gene:7706 TRIM25

ENSEMBL:ENSG00000121060 TRIM25

ENSEMBL:ENSG00000121060.19 TRIM25

HGNC:12932 TRIM25

KEGG Gene (Homo sapiens):7706 TRIM25

Monarch:7706 TRIM25

NCBI Gene:7706 TRIM25

OMIM:600453 TRIM25

UCSC:Q14258 TRIM25

Reference Transcript

RefSeq:NM_005082.4 TRIM25

Other Identifiers

11733885_a_at

11758537_s_at

1617_at

16846913

16846915

17126024

206911_PM_at

206911_at

224806_PM_at

224806_at

2712090

3335347

3763647

3763649

3763651

3763653

3763655

3763657

3763658

3763659

3763660

3763661

3763662

3763663

3763664

3763665

3763666

3763667

3763670

3763671

3763672

3763678

3763679

3763680

3763681

3763682

3763683

3763685

3763686

42053_at

55776_at

70996_at

7706

8016847

A_23_P15326

A_24_P236680

A_24_P936767

A_33_P3331366

A_33_P3332302

D21205_at

GE482009

GE57111

GE87112

GO:0002376

GO:0002753

GO:0003713

GO:0003723

GO:0003824

GO:0004842

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006351

GO:0006355

GO:0006511

GO:0006513

GO:0006979

GO:0010494

GO:0016567

GO:0016604

GO:0016740

GO:0016874

GO:0019076

GO:0023052

GO:0030163

GO:0030433

GO:0032880

GO:0033280

GO:0036211

GO:0039552

GO:0043123

GO:0043226

GO:0043627

GO:0044790

GO:0045087

GO:0045296

GO:0045893

GO:0046596

GO:0046597

GO:0046872

GO:0051091

GO:0051092

GO:0051607

GO:0061630

GO:0070936

GO:0098542

GO:0098772

GO:0140096

GO:0140110

GO:0140374

GO:0140678

GO:1990830

HMNXSV003019609

HMNXSV003052545

Hs.10362.0.S1_3p_at

ILMN_1813625

PH_hs_0034857

PH_hs_0038946

TC17001715.hg

TC17001716.hg

TC17002717.hg

g4827064_3p_at

p34438

Participates

as a component of

UBE2L6:TRIM25 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

TRIM25 [cytosol]

Inferred To

ftr84 [nucleoplasm] (Danio rerio)

Ghost homologue of TRIM25 [nucleoplasm] (Caenorhabditis elegans)

Ghost homologue of TRIM25 [nucleoplasm] (Drosophila melanogaster)

Ghost homologue of TRIM25 [nucleoplasm] (Plasmodium falciparum)

Ghost homologue of TRIM25 [nucleoplasm] (Xenopus tropicalis)

zgc:136954 [nucleoplasm] (Danio rerio)

si:dkey-218f9.5 [nucleoplasm] (Danio rerio)

TRIM25 [nucleoplasm] (Bos taurus)

TRIM25 [nucleoplasm] (Canis familiaris)

TRIM25 [nucleoplasm] (Danio rerio)

TRIM25 [nucleoplasm] (Gallus gallus)

TRIM25 [nucleoplasm] (Sus scrofa)

si:dkey-7b17.2 [nucleoplasm] (Danio rerio)

Homologues of TRIM25 [nucleoplasm] (Danio rerio)

zgc:172052 [nucleoplasm] (Danio rerio)

Trim25 [nucleoplasm] (Mus musculus)

Trim25 [nucleoplasm] (Rattus norvegicus)

zgc:153732 [nucleoplasm] (Danio rerio)

zgc:195240 [nucleoplasm] (Danio rerio)

Cross References

RefSeq

NP_005073.2

OpenTargets

ENSG00000121060

IntEnz

6.3.2.n3

GeneCards

Q14258

HPA

ENSG00000121060-TRIM25

Ensembl

ENSP00000445961, ENSG00000121060, ENSP00000323889, ENST00000316881, ENST00000537230

PRO

Q14258

Pharos - Targets

Q14258

HMDB Protein

HMDBP11982

PDB

5EYA, 5NT2, 5FER, 6FLM, 6FLN, 4LTB, 5NT1, 4CFG

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.86	13
UniProt:O95786 RIGI	4	PolyUb-DDX58 [cytosol] (R-HSA-6782770) K48polyUb-DDX58 [cytosol] (R-HSA-3080568) K63polyUb-DDX58 [cytosol] (R-HSA-918191) DDX58 [cytosol] (R-HSA-168917)	0.845	9
UniProt:A0A0B5AC19 NSS			0.59	6
UniProt:P03496 NS	2	NS1 [nucleoplasm] (R-FLU-169113) NS1 [cytosol] (R-FLU-169118)	0.556	3
UniProt:Q13283 G3BP1	1	G3BP1 [cytosol] (R-HSA-9729517)	0.524	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	3
UniProt:P59595 N	9	N [cytosol] (R-COV-9683625) p-S177-N [cytosol] (R-COV-9683754) ADPr-p-S177-N [cytosol] (R-COV-9686058) SUMO1-K62-ADPr-p-S177-N [cytosol] (R-COV-9682916) SUMO1-K62-ADPr-p-S177-N [viral capsid] (R-COV-9685478) SUMO1-K62-ADPr-p-S177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9683641) N [plasma membrane] (R-COV-9683611) SUMO1-K62-ADPr-p-S177-N [nucleolus] (R-COV-9683730) SUMO1-K62-ADPr-p-S177-N [plasma membrane] (R-COV-9686063)	0.463	2

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