POLD,POLE complete replication of damaged DNA after TLS

Stable Identifier
R-HSA-5653840
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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POLD,POLE complete replication of damaged DNA after TLS
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After DNA damage is bypassed by error-prone DNA polymerases capable of translesion DNA synthesis (TLS), the replicative complex composed of PCNA, DNA polymerases delta (POLD) or epsilon (POLE), RPA and RFC, completes the replication of damaged DNA (Park et al. 2014). Replicated damaged DNA may then be repaired through base excision or another DNA repair mechanism before the next round of DNA replication.
Literature References
PubMed ID Title Journal Year
24768535 Modification of PCNA by ISG15 plays a crucial role in termination of error-prone translesion DNA synthesis

Lee, SW, Seol, JH, Yang, SW, Yu, KR, Park, JM, Ka, SH, Jeon, YJ, Chung, CH

Mol. Cell 2014
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Catalyst Activity

DNA-directed DNA polymerase activity of PCNA:POLD,POLE:RPA:RFC:TLS-DNA Template [nucleoplasm]

Physical Entity
PCNA:POLD,POLE:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
Activity
DNA-directed DNA polymerase activity (GO:0003887)
Authored
Orlic-Milacic, M  (2014-12-11)
Reviewed
Borowiec, JA  (2015-01-07)
Created
Orlic-Milacic, M  (2014-12-02)
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