Reactome | SPRED2 [cytosol]

SPRED2 [cytosol]

Stable Identifier

R-HSA-5654211

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by FGFR (Homo sapiens)
    - Signaling by FGFR1 (Homo sapiens)
      - FGFRL1 modulation of FGFR1 signaling (Homo sapiens)
        
        FGFRL1 binds SPRED1/2 (Homo sapiens)
        
        FGFRL1 dimer:SPRED1/2 dimer [plasma membrane] (Homo sapiens)
        
        SPRED1/2 dimer [cytosol] (Homo sapiens)
        
        SPRED2 dimer [cytosol] (Homo sapiens)
        
        SPRED2 [cytosol] (Homo sapiens)
        
        SPRED1/2 dimer [cytosol] (Homo sapiens)
        
        SPRED2 dimer [cytosol] (Homo sapiens)
        
        SPRED2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q7Z698 SPRED2

Gene Names

SPRED2

Chain

chain:1-418

Reference Genes

BioGPS Gene:200734 SPRED2

COSMIC (genes):SPRED2 SPRED2

CTD Gene:200734 SPRED2

dbSNP Gene:200734 SPRED2

ENSEMBL:ENSG00000198369 SPRED2

HGNC:17722 SPRED2

KEGG:hsa:200734 SPRED2

Monarch:200734 SPRED2

NCBI Gene:200734 SPRED2

OMIM:609292 SPRED2

UCSC:Q7Z698 SPRED2

Reference Transcript

Other Identifiers

11717655_a_at

11717656_a_at

11741055_a_at

16898403

200734

212458_PM_at

212458_at

212466_PM_at

212466_at

2556751

2556753

2556754

2556755

2556756

2556757

2556758

2556759

2556760

2556761

2556762

2556763

2556764

2556765

2556766

2556769

2556770

2556781

2556782

2556783

2556784

2556785

2556786

2556787

2556790

2556792

2556793

2556801

2556802

2556803

2556824

2556825

2556826

2556827

2556828

40602_at

46119_at

8052689

A_24_P315535

A_32_P225854

GE54478

GE660952

GE899709

GO:0005173

GO:0005515

GO:0005737

GO:0005829

GO:0005886

GO:0007275

GO:0009966

GO:0010719

GO:0010801

GO:0016020

GO:0019901

GO:0030291

GO:0030512

GO:0030658

GO:0031410

GO:0043226

GO:0043409

GO:0043517

GO:0048856

GO:0070373

GO:0090311

GO:0098772

GO:1902747

HMNXSV003007573

HMNXSV003014070

Hs.173108.1.A1_3p_at

Hs.173108.1.A2_3p_at

ILMN_1791232

PH_hs_0010379

TC02001923.hg

TC02004296.hg

Participates

as a component of

SPRED2 dimer [cytosol] (Homo sapiens)

Other forms of this molecule

SPRED2 [plasma membrane]

Inferred To

Spred [cytosol] (Drosophila melanogaster)

spred2 [cytosol] (Danio rerio)

spred2 [cytosol] (Xenopus tropicalis)

SPRED2 [cytosol] (Canis familiaris)

SPRED2 [cytosol] (Gallus gallus)

SPRED2 [cytosol] (Sus scrofa)

Spred2 [cytosol] (Mus musculus)

Spred2 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_861449.2, NP_001121682.1

ENSEMBL

ENST00000356388, ENST00000443619, ENSP00000393697, ENSP00000348753

OpenTargets

ENSG00000198369

HPA

ENSG00000198369-SPRED2

PRO

Q7Z698

Pharos - Targets

Q7Z698

PDB

8EQ5, 2JP2

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:P36957 DLST	5	Lipo-K110-DLST [mitochondrial matrix] (R-HSA-69993) SuccinyllipoH2-K110-DLST [mitochondrial matrix] (R-HSA-9853502) LipoH2-K110-DLST [mitochondrial matrix] (R-HSA-9853485) DLST [mitochondrial matrix] (R-HSA-6792574) GlutaryllipoH2-K110-DLST [mitochondrial matrix] (R-HSA-9858581)	0.556	3
UniProt:P27797 CALR	6	CALR [lumenal side of endoplasmic reticulum membrane] (R-HSA-985502) CALR [endoplasmic reticulum lumen] (R-HSA-195905) CALR [extracellular region] (R-HSA-2197641) CALR [endocytic vesicle lumen] (R-HSA-2239448) CALR [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863866) CALR [phagocytic vesicle membrane] (R-HSA-1236879)	0.556	3
UniProt:P02545 LMNA	3	LMNA(1-567)-p-RAF1(279-648) fusion [cytosol] (R-HSA-6802537) LMNA(1-567)-RAF1(279-648) fusion [cytosol] (R-HSA-6802399) LMNA(1-646) [nuclear envelope] (R-HSA-535479)	0.556	3
UniProt:P47897 QARS1	2	QARS [cytosol] (R-HSA-379615) QARS [mitochondrial matrix] (R-HSA-379592)	0.556	3
UniProt:P29474 NOS3	9	2xPalmC-MyrG-p-S1177-NOS3 [plasma membrane] (R-HSA-202139) 2xPalmC-MyrG-NOS3 [plasma membrane] (R-HSA-534993) 2xPalmC-MyrG-NOS3 [Golgi membrane] (R-HSA-203769) MyrG-NOS3 [cytosol] (R-HSA-203687) MyrG-NOS3 [Golgi membrane] (R-HSA-534995) NOS3 [cytosol] (R-HSA-202114) 2xPalmC-MyrG-NOS3 [endocytic vesicle membrane] (R-HSA-535007) 2xPalmC-MyrG-p-S633-NOS3 [plasma membrane] (R-HSA-9861341) 2xPalmC-MyrG-p-S1177,S1179-NOS3 [plasma membrane] (R-HSA-9860783)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	6
UniProt:P14136 GFAP	3	p-GFAP [lysosomal membrane] (R-HSA-9626054) GFAP [lysosomal membrane] (R-HSA-9625195) GFAP [cytosol] (R-HSA-1253311)	0.556	3
UniProt:P19404 NDUFV2	1	NDUFV2 [mitochondrial inner membrane] (R-HSA-163939)	0.556	3
UniProt:Q53GS7 GLE1	1	GLE1 [nucleoplasm] (R-HSA-8932905)	0.556	3

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