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KAL1 [extracellular region]
Stable Identifier
R-HSA-5654345
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Anosmin, ADMLX, KAL, KALIG1
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by FGFR (Homo sapiens)
Signaling by FGFR1 (Homo sapiens)
FGFR1 ligand binding and activation (Homo sapiens)
FGFR1c ligand binding and activation (Homo sapiens)
FGFR1c binds to FGF (Homo sapiens)
FGFR1c:KAL1 [plasma membrane] (Homo sapiens)
KAL1 [extracellular region] (Homo sapiens)
KAL1:HS [extracellular region] (Homo sapiens)
KAL1 [extracellular region] (Homo sapiens)
KAL1 binds HS (Homo sapiens)
KAL1 [extracellular region] (Homo sapiens)
KAL1:HS [extracellular region] (Homo sapiens)
KAL1 [extracellular region] (Homo sapiens)
Negative regulation of FGFR1 signaling (Homo sapiens)
KAL1 binds FGFR1c (Homo sapiens)
FGFR1c:KAL1 [plasma membrane] (Homo sapiens)
KAL1 [extracellular region] (Homo sapiens)
KAL1 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P23352 ANOS1
Gene Names
ANOS1, ADMLX, KAL, KAL1, KALIG1
Chain
signal peptide:1-24, chain:25-680
Reference Genes
BioGPS Gene:3730 ANOS1
COSMIC (genes):ANOS1 ANOS1
CTD Gene:3730 ANOS1
dbSNP Gene:3730 ANOS1
ENSEMBL:ENSG00000011201 ANOS1
HGNC:6211 ANOS1
KEGG:hsa:3730 ANOS1
Monarch:3730 ANOS1
NCBI Gene:3730 ANOS1
OMIM:300836 ANOS1
UCSC:P23352 ANOS1
Reference Transcript
RefSeq:NM_000216.3 ANOS1
Other Identifiers
11726396_x_at
11726397_at
11758166_s_at
17108959
17125718
17125722
205206_PM_at
205206_at
33158_at
3730
3998769
3998770
3998771
3998772
3998773
3998774
3998775
3998776
3998778
3998779
3998780
3998781
3998783
3998784
3998787
3998791
3998792
3998793
3998794
3998795
3998796
3998803
3998804
3998805
3998808
3998820
3998824
3998825
3998826
4030295
4030303
4030304
4030313
8171248
A_23_P429950
GE558096
GE58178
GO:0004867
GO:0005198
GO:0005201
GO:0005515
GO:0005576
GO:0005615
GO:0005886
GO:0006935
GO:0007155
GO:0007411
GO:0008201
GO:0009986
GO:0030154
GO:0030182
GO:0030312
GO:0030414
GO:0031012
GO:0098772
HMNXSV003048922
HMNXSV003051071
Hs.283905.0.S1_3p_s_at
ILMN_1750373
M97252_at
PH_hs_0018548
TC0X000829.hg
TC0Y000261.hg
X60299_s_at
g4557682_3p_at
Participates
as an input of
KAL1 binds HS (Homo sapiens)
KAL1 binds FGFR1c (Homo sapiens)
as a component of
FGFR1c:KAL1 [plasma membrane] (Homo sapiens)
KAL1:HS [extracellular region] (Homo sapiens)
Inferred To
Kal1 [extracellular region]
(Drosophila melanogaster)
anos1 [extracellular region]
(Xenopus tropicalis)
KAL1 [extracellular region]
(Gallus gallus)
ANOS1 [extracellular region]
(Canis familiaris)
ANOS1 [extracellular region]
(Sus scrofa)
kal-1 [extracellular region]
(Caenorhabditis elegans)
anos1a [extracellular region]
(Danio rerio)
anos1b [extracellular region]
(Danio rerio)
Homologues of KAL1 [extracellular region]
(Danio rerio)
Cross References
RefSeq
NP_000207.2
ENSEMBL
ENST00000262648
,
ENSP00000262648
,
ENSG00000011201
OpenTargets
ENSG00000011201
GeneCards
ANOS1
HPA
ENSG00000011201-ANOS1
PRO
P23352
Pharos - Targets
P23352
GlyGen
P23352
Orphanet
ANOS1
PDB
1ZLG
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P11362 FGFR1
9
FGFR1 [plasma membrane]
(R-HSA-9756433)
p-8Y- FGFR1 R576W [plasma membrane]
(R-HSA-2023361)
p-8Y-FGFR1 N546K [plasma membrane]
(R-HSA-2023358)
p-8Y-FGFR1 K656E [plasma membrane]
(R-HSA-2023356)
p-6Y-FGFR1(22-763):TACC1(571-805) fusion [plasma membrane]
(R-HSA-8853142)
FGFR1 R576W [plasma membrane]
(R-HSA-2011844)
FGFR1 N546K [plasma membrane]
(R-HSA-1614377)
FGFR1 K656E [plasma membrane]
(R-HSA-1614373)
FGFR1(22-763):TACC1(571-805) fusion [plasma membrane]
(R-HSA-8853241)
0.626
7
UniProt:Q9UMX0 UBQLN1
1
UBQLN1 [cytosol]
(R-HSA-8866006)
0.556
3
UniProt:P61601 NCALD
1
NCALD [cytosol]
(R-HSA-450887)
0.556
3
ChEBI:28304 HEPARIN
0.544
2
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