Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange

Stable Identifier
R-HSA-5654402
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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SOS, recruited by GRB2:p-FRS2 to activated FGFR, activates RAS nucleotide exchange from the inactive GDP-bound to the active GTP-bound state.
Literature References
PubMed ID Title Journal Year
8493579 Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2

Gale, NW, Camonis, JH, Chardin, P, Schlessinger, J, Wigler, MH, Bar-Sagi, D, Van Aelst, L

Science 1993
Participants
Participates
Catalyst Activity

guanyl-nucleotide exchange factor activity of Activated FGFR2:pY-SHC1:GRB2:SOS1 [plasma membrane]

Orthologous Events
Authored
Reviewed
Created
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