Reactome | PI-3K cascade:FGFR1

PI-3K cascade:FGFR1

Stable Identifier

R-HSA-5654689

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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The ability of growth factors to protect from apoptosis is primarily due to the activation of the AKT survival pathway. P-I-3-kinase dependent activation of PDK leads to the activation of AKT which in turn affects the activity or expression of pro-apoptotic factors, which contribute to protection from apoptosis. AKT activation also blocks the activity of GSK-3b which could lead to additional antiapoptotic signals.

Literature References

PubMed ID	Title	Journal	Year
12558974	The role of phosphatidylinositol 3-kinase in neural cell adhesion molecule-mediated neuronal differentiation and survival Pedersen, MV, Risell, M, Meyer, M, Kolkova, K, Berezin, V, Bock, E, Ditlevsen, DK, Kohler, LB	J Neurochem	2003
10918587	Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4 Tynan, JA, Donoghue, DJ, Hart, KC, Kanemitsu, MY, Robertson, SC, Meyer, AN	Oncogene	2000
11057895	Cell signaling by receptor tyrosine kinases Schlessinger, J	Cell	2000
15863030	Cellular signaling by fibroblast growth factor receptors Schlessinger, J, Eswarakumar, VP, Lax, I	Cytokine Growth Factor Rev	2005
12089343	The phosphatidylinositol 3-kinase/Akt signaling pathway modulates the endocrine differentiation of trophoblast cells Chapman, BM, Jones, SR, Dai, G, Kamei, T, MCGonigle, KL, Soares, MJ	Mol Endocrinol	2002