Reactome | LAMTOR5 [lysosomal membrane]

LAMTOR5 [lysosomal membrane]

Stable Identifier

R-HSA-5655441

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

lysosomal membrane

Synonyms

Ragulator complex protein LAMTOR5, LTOR5_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:Q6IAA8 LAMTOR1

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External Reference Information

External Reference

UniProt:O43504 LAMTOR5

Gene Names

LAMTOR5, HBXIP, XIP

Chain

chain:1-91

Reference Genes

BioGPS Gene:10542 LAMTOR5

COSMIC (genes):LAMTOR5 LAMTOR5

CTD Gene:10542 LAMTOR5

dbSNP Gene:10542 LAMTOR5

ENSEMBL:ENSG00000134248 LAMTOR5

ENSEMBL_homo_sapiens_GENE:ENSG00000134248.14 LAMTOR5

HGNC:17955 LAMTOR5

KEGG Gene (Homo sapiens):10542 LAMTOR5

Monarch:10542 LAMTOR5

NCBI Gene:10542 LAMTOR5

OMIM:608521 LAMTOR5

UCSC:O43504 LAMTOR5

Reference Transcript

RefSeq:NM_006402.2 LAMTOR5

Other Identifiers

10542

11742893_at

202299_PM_s_at

202299_s_at

202300_PM_at

202300_at

2427501

2427502

2427503

2427504

2427508

2427512

2427513

38054_at

7918437

A_23_P115137

GE61235

GE636049

GO:0005085

GO:0005515

GO:0005737

GO:0005764

GO:0005765

GO:0005768

GO:0005773

GO:0005829

GO:0006351

GO:0006355

GO:0008361

GO:0009615

GO:0010628

GO:0012501

GO:0019079

GO:0023052

GO:0031410

GO:0031902

GO:0032008

GO:0032757

GO:0032991

GO:0038202

GO:0043066

GO:0043123

GO:0043154

GO:0043226

GO:0051092

GO:0060090

GO:0061462

GO:0071230

GO:0071986

GO:0098772

GO:1900182

GO:1904263

GO:1905636

GO:1990877

HMNXSV003018066

ILMN_2220518

PH_hs_0017528

g5454169_3p_a_at

Participates

as an input of

Formation of Ragulator complex (Homo sapiens)

as a component of

Ragulator [lysosomal membrane] (Homo sapiens)

Inferred To

Ghost homologue of LAMTOR5 [lysosomal membrane] (Saccharomyces cerevisiae)

Ghost homologue of LAMTOR5 [lysosomal membrane] (Schizosaccharomyces pombe)

LAMTOR5 [lysosomal membrane] (Bos taurus)

LAMTOR5 [lysosomal membrane] (Canis familiaris)

LAMTOR5 [lysosomal membrane] (Dictyostelium discoideum)

LAMTOR5 [lysosomal membrane] (Gallus gallus)

LAMTOR5 [lysosomal membrane] (Sus scrofa)

lmtr-5 [lysosomal membrane] (Caenorhabditis elegans)

Lamtor5 [lysosomal membrane] (Drosophila melanogaster)

Lamtor5 [lysosomal membrane] (Mus musculus)

Lamtor5 [lysosomal membrane] (Rattus norvegicus)

lamtor5 [lysosomal membrane] (Danio rerio)

lamtor5 [lysosomal membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_006393.2

OpenTargets

ENSG00000134248

HPA

ENSG00000134248-LAMTOR5

GeneCards

O43504

Ensembl

ENST00000602318, ENSP00000473439, ENSG00000134248

PRO

O43504

Pharos - Targets

O43504

PDB

5Y38, 5YK5, 6B9X, 5Y39, 8DHB, 6NZD, 3MSH, 7UX2, 7T3A, 7T3B, 6EHP, 5Y3A, 5VOK, 7T3C, 6WJ2, 6EHR, 6WJ3, 7UXC, 5X6U, 6U62, 6ULG, 7UXH, 3MS6, 5X6V, 5YK3

Interactors (26)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q0VGL1 LAMTOR4	1	LAMTOR4 [lysosomal membrane] (R-HSA-5655432)	0.953	23
UniProt:Q05516 ZBTB16	1	ZBTB16 [cytosol] (R-HSA-976047)	0.83	8
UniProt:Q6IAA8 LAMTOR1	5	LAMTOR1 [specific granule membrane] (R-HSA-6799631) LAMTOR1 [lysosomal membrane] (R-HSA-5653582) LAMTOR1 [ficolin-1-rich granule membrane] (R-HSA-6801003) LAMTOR1 [plasma membrane] (R-HSA-6806270) LAMTOR1 [azurophil granule membrane] (R-HSA-6799633)	0.826	12
UniProt:Q9Y2Q5 LAMTOR2	5	LAMTOR2 [specific granule membrane] (R-HSA-6800168) LAMTOR2 [plasma membrane] (R-HSA-6806286) LAMTOR2 [tertiary granule membrane] (R-HSA-6800165) LAMTOR2 [endosome membrane] (R-HSA-5693293) LAMTOR2 [lysosomal membrane] (R-HSA-5653583)	0.812	10
UniProt:Q8NBW4 SLC38A9	1	SLC38A9 [lysosomal membrane] (R-HSA-5215938)	0.723	6
UniProt:Q8NHQ1 CEP70	1	CEP70 [cytosol] (R-HSA-380257)	0.718	6
UniProt:Q9HB90 RRAGC	1	RRAGC [cytosol] (R-HSA-5653949)	0.69	7
UniProt:O15273 TCAP	1	TCAP [cytosol] (R-HSA-390571)	0.666	5
UniProt:Q7L523 RRAGA	2	K63polyUb-K142,K220,K230,K244-RRAGA [cytosol] (R-HSA-8938830) RRAGA [cytosol] (R-HSA-5653577)	0.643	6
UniProt:Q8N122 RPTOR	3	RPTOR [nucleoplasm] (R-HSA-5083664) RPTOR [cytosol] (R-HSA-3006727) p-S722,S792-RPTOR [cytosol] (R-HSA-3132767)	0.643	4
UniProt:Q9UHA4 LAMTOR3	5	LAMTOR3 [specific granule membrane] (R-HSA-6800178) LAMTOR3 [plasma membrane] (R-HSA-6806307) LAMTOR3 [tertiary granule membrane] (R-HSA-6800189) LAMTOR3 [endosome membrane] (R-HSA-5693294) LAMTOR3 [lysosomal membrane] (R-HSA-5653581)	0.643	5
UniProt:P22607 FGFR3	20	FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853144) FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853131) FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853152) FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853124) FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853125) FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853127) FGFR3 K650T [plasma membrane] (R-HSA-1614411) FGFR3 K650N [plasma membrane] (R-HSA-1614406) FGFR3 K650M [plasma membrane] (R-HSA-1614402) FGFR3 K650Q [plasma membrane] (R-HSA-1614410) FGFR3 A391E [plasma membrane] (R-HSA-1614390) FGFR3 K650E [plasma membrane] (R-HSA-1614400) FGFR3 G380R [plasma membrane] (R-HSA-1614398) FGFR3 G382D [plasma membrane] (R-HSA-2018740) FGFR3 805fs*141 [plasma membrane] (R-HSA-1614387) FGFR3 [plasma membrane] (R-HSA-2038357) FGFR3 S371C [plasma membrane] (R-HSA-1614421) FGFR3 Y373C [plasma membrane] (R-HSA-1614424) FGFR3 G370C [plasma membrane] (R-HSA-1614394) FGFR3 R248C [plasma membrane] (R-HSA-1614419)	0.556	3
UniProt:P49591 SARS1	1	SARS [cytosol] (R-HSA-379691)	0.556	3
UniProt:O15392 BIRC5	3	ub-BIRC5 [cytosol] (R-HSA-8955933) BIRC5 [nucleoplasm] (R-HSA-4655344) BIRC5 [cytosol] (R-HSA-50851)	0.556	3
UniProt:Q0VDC6 Q0VDC6			0.556	3
UniProt:Q9UMX0 UBQLN1	1	UBQLN1 [cytosol] (R-HSA-8866006)	0.556	3
UniProt:P06396 GSN	7	GSN(200-270) [extracellular region] (R-HSA-976940) GSN [secretory granule lumen] (R-HSA-6801486) GSN [extracellular region] (R-HSA-6806510) GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN(404-782) [cytosol] (R-HSA-350272) GSN(28-403) [cytosol] (R-HSA-201618) GSN [cytosol] (R-HSA-350275)	0.556	3
UniProt:Q9Y3D8 AK6	1	AK6 [nucleoplasm] (R-HSA-6788786)	0.556	3
UniProt:Q14957 GRIN2C	3	GRIN2C [plasma membrane] (R-HSA-419560) p-Y-GRIN2C [plasma membrane] (R-HSA-9612189) GRIN2C [endoplasmic reticulum membrane] (R-HSA-9609761)	0.556	3
UniProt:P50222 MEOX2			0.556	3
UniProt:P54652 HSPA2	2	HSPA2 [cytosol] (R-HSA-3371408) HSPA2 [nucleoplasm] (R-HSA-912480)	0.556	3
UniProt:Q9Y2X7 GIT1	2	GIT1 [cytosol] (R-HSA-430326) p-Y383-GIT1 [cytosol] (R-HSA-3928463)	0.553	2
UniProt:P68104 EEF1A1	7	Me3K79-EEF1A1 [cytosol] (R-HSA-8932212) Me3K318-EEF1A1 [cytosol] (R-HSA-8932419) EEF1A1 [secretory granule lumen] (R-HSA-6801479) EEF1A1 [extracellular region] (R-HSA-6806456) EEF1A1 [ficolin-1-rich granule lumen] (R-HSA-6801528) EEF1A1 [cytosol] (R-HSA-156905) EEF1A1 [lysosomal membrane] (R-HSA-9626022)	0.553	2
UniProt:Q9NQL2 RRAGD	1	RRAGD [cytosol] (R-HSA-5653953)	0.527	3
UniProt:Q5VZM2 RRAGB	1	RRAGB [cytosol] (R-HSA-5653579)	0.527	2
UniProt:Q9WMX2-PRO_0000037547			0.499	2

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