Reactome | POLZ elongates POLI-incorporated dNMP

POLZ elongates POLI-incorporated dNMP

Stable Identifier

R-HSA-5656158

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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After it incorporates a dNMP opposite to a damaged template base, DNA polymerase iota (POLI) is unable to efficiently elongate the DNA strand further. The elongation step is performed by the DNA polymerase zeta complex (POLZ), composed of REV3L and MAD2L2 subunits (Johnson et al. 2000). POLK has also been implicated in the elongation step (Washington et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
10984059	Eukaryotic polymerases iota and zeta act sequentially to bypass DNA lesions Johnson, RE, Haracska, L, Washington, MT, Prakash, L, Prakash, S	Nature	2000
15199127	Efficient and error-free replication past a minor-groove DNA adduct by the sequential action of human DNA polymerases iota and kappa Washington, MT, Lloyd, RS, Johnson, RE, Prakash, L, Wolfle, WT, Minko, IG, Harris, TM, Prakash, S	Mol. Cell. Biol.	2004