MGMT-mediated DNA damage reversal

Stable Identifier
R-HSA-5657655
Type
Pathway
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
MGMT-mediated DNA damage reversal
Click the image above or here to open this pathway in the Pathway Browser
Reactive cellular catabolites can cause DNA damage by 6-O-methylation of guanine. 6-O-methylguanine can pair ambiguously with both C and T, and cause transition mutations. Active reversal of such damage can be facilitated by MGMT, a protein that has 6-O-methylguanine-DNA methyltransferase activity (Mitra and Kaina 1993).
Literature References
PubMed ID Title Journal Year
8434121 Regulation of repair of alkylation damage in mammalian genomes.

Mitra, S, Kaina, B

Prog Nucleic Acid Res Mol Biol 1993
Participants
Events
Participates
as an event of
Event Information
Go Biological Process
DNA dealkylation involved in DNA repair (0006307)
Authored
Pegg, AE  (2004-02-04)
Reviewed
Joshi-Tope, G  (2004-02-04)
Gillespie, ME  (2015-02-06)
Created
Orlic-Milacic, M  (2014-12-16)
Cite Us!