Reactome | isomaltose + H2O => 2 D-glucose (sucrase-isomaltase)

isomaltose + H2O => 2 D-glucose (sucrase-isomaltase)

Stable Identifier

R-HSA-5659861

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

Synonyms

SI (sucrase-isomaltase) hydrolyzes isomaltose to yield glucose

ReviewStatus

5/5

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isomaltose + H2O => 2 D-glucose (sucrase-isomaltase)

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The alpha-1,6 linkages of extracellular isomaltose are hydrolyzed to yield glucose in a reaction catalyzed by sucrase-maltase (Sim et al. 2010). In the body, this enzyme is found as a dimer on the external face of enterocytes in microvilli of the small intestine (Hauri et al. 1985). The predominant form of mature SI in the membrane is a dimer, as established from a variety of studies of the processing of the porcine enzyme (Cowell et al. 1986; Danielsen 1994) and crystallographic studies of the human one (Sim et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
20356844	Structural basis for substrate selectivity in human maltase-glucoamylase and sucrase-isomaltase N-terminal domains Rose, DR, Sim, L, Pinto, BM, Willemsma, C, Mohan, S, Naim, HY	J. Biol. Chem.	2010
3897250	Expression and intracellular transport of microvillus membrane hydrolases in human intestinal epithelial cells Hauri, HP, Fransen, JA, Bienz, D, Marxer, A, Sterchi, EE	J Cell Biol	1985
7906143	Dimeric assembly of enterocyte brush border enzymes Danielsen, EM	Biochemistry	1994
3800897	Topology and quaternary structure of pro-sucrase/isomaltase and final-form sucrase/isomaltase Tranum-Jensen, J, Cowell, GM, Sjöström, H, Norén, O	Biochem J	1986