Expression of SNCB

Stable Identifier
R-HSA-5660530
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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Expression of SNCB
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The SNCB (beta-synuclein) gene is transcribed to yield mRNA which is translated to yield protein (Lavedan et al. 1998). Transcription of SNCB is up-regulated by copper via a metal response binding element in the 5' promoter that binds MTF1 (McHugh et al. 2011).
Literature References
PubMed ID Title Journal Year
21386983 Transcriptional regulation of the beta-synuclein 5'-promoter metal response element by metal transcription factor-1

McHugh, PC, Wright, JA, Brown, DR

PLoS ONE 2011
9806846 Genomic organization and expression of the human beta-synuclein gene (SNCB)

Nussbaum, RL, Polymeropoulos, MH, Dutra, A, Torres, R, Lavedan, C, Buchholtz, S, Leroy, E, Dehejia, A

Genomics 1998
Participants
Input
Output
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as an event of
This event is regulated
Positively by
Regulator
MTF1 dimer:12Zn2+:SNCB gene [nucleoplasm] (Homo sapiens)
Authored
May, B  (2014-12-28)
Reviewed
Brown, DR  (2017-01-12)
Created
May, B  (2015-01-05)
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