Caspase-8 cleaves IL1B precursor

Stable Identifier
R-HSA-5660663
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Caspase-8 cleaves IL1B precursor
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Interleukin-1beta (IL1B) is secreted as inactive precursor, and the processing of pro-IL1B depends on cleavage by proteases. Active caspase-8 inflammasome is capable of cleaving the 31-kDa inactive IL1B precursor form into the bioactive 17-kDa IL1B.
Literature References
PubMed ID Title Journal Year
22267217 Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1? via a noncanonical caspase-8 inflammasome

Geijtenbeek, TB, Gringhuis, SI, Boekhout, T, Theelen, B, Wevers, BA, van der Vlist, M, Kaptein, TM

Nat. Immunol. 2012
1574116 A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes

Chapman, KT, Calaycay, JR, Aunins, J, Weidner, JR, Thornberry, NA, Miller, DK, Molineaux, SM, Kostura, MJ, Bull, HG, Howard, AD

Nature 1992
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Output
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as an event of
Catalyst Activity

cysteine-type endopeptidase activity of MALT1 oligomers:active caspase-8:ASC [cytosol]

Physical Entity
MALT1 oligomers:active caspase-8:ASC [cytosol] (Homo sapiens)
Activity
cysteine-type endopeptidase activity (GO:0004197)
Orthologous Events
Caspase-8 cleaves IL1B precursor (Bos taurus)
Caspase-8 cleaves IL1B precursor (Canis familiaris)
Caspase-8 cleaves IL1B precursor (Mus musculus)
Caspase-8 cleaves IL1B precursor (Rattus norvegicus)
Caspase-8 cleaves IL1B precursor (Sus scrofa)
Authored
Garapati, P V  (2015-01-05)
Reviewed
Geijtenbeek, TB  (2014-09-02)
Created
Garapati, P V  (2015-01-05)
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