JMJD6 demethylates Me2R3-histone H3

Stable Identifier
R-HSA-5661122
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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JMJD6 demethylates Me2R3-histone H3
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JMJD6 catalyses demethylation of mono- or di-methylated arginine-3 of histone H3 (H3R2Me1/2) and arginine-4 of histone H4 (H4R3Me1/2) (Chang et al. 2007). Non-histone substrates of JMJD6 arginine demethylation have also been reported (Poulard et al. 2014, Lawrence et al. 2014). Subsequent to its characterization as an arginine demethylase, JMJD6 was reported to be a lysine hydroxylase (Webby et al 2009).
Literature References
PubMed ID Title Journal Year
17947579 JMJD6 is a histone arginine demethylase

Chang, B, Chen, Y, Zhao, Y, Bruick, RK

Science 2007
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Catalyst Activity

histone demethylase activity of JMJD6 [nucleoplasm]

Physical Entity
JMJD6 [nucleoplasm] (Homo sapiens)
Activity
histone demethylase activity (GO:0032452)
Orthologous Events
JMJD6 demethylates Me2R3-histone H3 (Bos taurus)
JMJD6 demethylates Me2R3-histone H3 (Caenorhabditis elegans)
JMJD6 demethylates Me2R3-histone H3 (Canis familiaris)
JMJD6 demethylates Me2R3-histone H3 (Danio rerio)
JMJD6 demethylates Me2R3-histone H3 (Mus musculus)
JMJD6 demethylates Me2R3-histone H3 (Rattus norvegicus)
JMJD6 demethylates Me2R3-histone H3 (Sus scrofa)
Authored
Jupe, S  (2013-03-12)
Reviewed
Schofield, CJ  (2014-05-08)
Walport, LJ  (2014-05-08)
Hopkinson, J  (2014-05-08)
Created
Jupe, S  (2015-01-09)
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