JMJD6 demethylates MeR4-HIST1H4

Stable Identifier
R-HSA-5661124
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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JMJD6 demethylates MeR4-HIST1H4
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JMJD6 catalyses demethylation of mono- or di-methylated arginine-3 of histone H3 (H3R2Me1/2) and arginine-4 of histone H4 (H4R3Me1/2) (Chang et al. 2007). Non-histone substrates of JMJD6 arginine demethylation have also been reported (Poulard et al. 2014, Lawrence et al. 2014). Subsequent to its characterization as an arginine demethylase, JMJD6 was reported to be a lysine hydroxylase (Webby et al 2009).
Literature References
PubMed ID Title Journal Year
17947579 JMJD6 is a histone arginine demethylase

Zhao, Y, Chen, Y, Bruick, RK, Chang, B

Science 2007
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Output
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Catalyst Activity

histone demethylase activity of JMJD6 [nucleoplasm]

Physical Entity
JMJD6 [nucleoplasm] (Homo sapiens)
Activity
histone demethylase activity (GO:0032452)
Orthologous Events
JMJD6 demethylates MeR4-HIST1H4 (Bos taurus)
JMJD6 demethylates MeR4-HIST1H4 (Caenorhabditis elegans)
JMJD6 demethylates MeR4-HIST1H4 (Canis familiaris)
JMJD6 demethylates MeR4-HIST1H4 (Danio rerio)
JMJD6 demethylates MeR4-HIST1H4 (Drosophila melanogaster)
JMJD6 demethylates MeR4-HIST1H4 (Gallus gallus)
JMJD6 demethylates MeR4-HIST1H4 (Mus musculus)
JMJD6 demethylates MeR4-HIST1H4 (Rattus norvegicus)
JMJD6 demethylates MeR4-HIST1H4 (Sus scrofa)
Authored
Jupe, S  (2013-03-12)
Reviewed
Walport, LJ  (2014-05-08)
Hopkinson, J  (2014-05-08)
Schofield, CJ  (2014-05-08)
Created
Jupe, S  (2015-01-09)
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