MT1A binds arsenic

Stable Identifier
R-HSA-5661230
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
MT1A binds arsenic
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Metallothionein MT1A binds 6 atoms of arsenic(III), 3 atoms at the N-terminal beta domain and 3 atoms at the C-terminal alpha domain (Ngu and Stillman 2006, Irvine et al. 2013). Each arsenic atom binds 3 cysteine thiols (Ngu and Stillman 2006, Irvine et al. 2013).
Literature References
PubMed ID Title Journal Year
16984198 Arsenic binding to human metallothionein

Stillman, MJ, Ngu, TT

J. Am. Chem. Soc. 2006
23523794 Cysteine accessibility during As3+ metalation of the ?- and ?-domains of recombinant human MT1a

Stillman, MJ, Summers, KL, Irvine, GW

Biochem. Biophys. Res. Commun. 2013
Participants
Input
Output
Participates
as an event of
Orthologous Events
MT1A binds arsenic (Bos taurus)
MT1A binds arsenic (Canis familiaris)
MT1A binds arsenic (Danio rerio)
MT1A binds arsenic (Gallus gallus)
MT1A binds arsenic (Mus musculus)
MT1A binds arsenic (Rattus norvegicus)
MT1A binds arsenic (Sus scrofa)
Authored
May, B  (2015-01-07)
Reviewed
Atrian, S  (2015-09-19)
Created
May, B  (2015-01-10)
Cite Us!