Reactome | p-CDC6 [nucleoplasm]

p-CDC6 [nucleoplasm]

Stable Identifier

R-HSA-5661317

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

phosphorylated Cdc6

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q99741 CDC6

Gene Names

CDC6, CDC18L

Chain

chain:1-560

Reference Genes

BioGPS Gene:990 CDC6

COSMIC (genes):CDC6 CDC6

CTD Gene:990 CDC6

dbSNP Gene:990 CDC6

ENSEMBL:ENSG00000094804 CDC6

ENSEMBL_homo_sapiens_GENE:ENSG00000094804.12 CDC6

HGNC:1744 CDC6

KEGG Gene (Homo sapiens):990 CDC6

Monarch:990 CDC6

NCBI Gene:990 CDC6

OMIM:602627 CDC6

UCSC:Q99741 CDC6

Reference Transcript

RefSeq:NM_001254.3 CDC6

Other Identifiers

11743064_at

11743065_at

1536_at

16834056

203967_PM_at

203967_at

203968_PM_s_at

203968_s_at

36839_at

3720897

3720900

3720901

3720902

3720903

3720904

3720905

3720906

3720907

3720910

3720913

3720914

3720916

3720917

3720918

3720920

8007071

990

A_14_P127674

A_23_P49972

A_33_P3218450

GE59420

GO:0000076

GO:0000079

GO:0000166

GO:0000278

GO:0000910

GO:0000922

GO:0003824

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005856

GO:0006260

GO:0006270

GO:0007049

GO:0007059

GO:0007089

GO:0008156

GO:0008285

GO:0016787

GO:0016887

GO:0019900

GO:0023052

GO:0030071

GO:0032467

GO:0033314

GO:0036211

GO:0043226

GO:0045171

GO:0048146

GO:0051233

GO:0051301

GO:0051984

GO:0072686

GO:0140657

GO:1904117

GO:1904385

HMNXSV003051890

ILMN_1785914

PH_hs_0033144

TC17000495.hg

U77949_at

g4502702_3p_a_at

p7354

Participates

as an input of

Phosphorylated Cdc6 is exported from the nucleus (Homo sapiens)

as an output of

Cdc6 protein is phosphorylated by CDK (Homo sapiens)

Other forms of this molecule

CDC6 [nucleoplasm]

p-CDC6 [cytosol]

CDC6 [cytosol]

Inferred To

phospho-cdc6 [nucleoplasm] (Danio rerio)

phospho-cdc6 [nucleoplasm] (Xenopus tropicalis)

phospho-Cdc6 [nucleoplasm] (Drosophila melanogaster)

phospho-Cdc6 [nucleoplasm] (Rattus norvegicus)

phospho-cdc-6 [nucleoplasm] (Caenorhabditis elegans)

phospho-p-CDC6 [nucleoplasm] (Dictyostelium discoideum)

phospho-p-CDC6 [nucleoplasm] (Mus musculus)

phospho-p-CDC6 [nucleoplasm] (Plasmodium falciparum)

phospho-p-CDC6 [nucleoplasm] (Saccharomyces cerevisiae)

phospho-p-CDC6 [nucleoplasm] (Schizosaccharomyces pombe)

phospho-CDC6 [nucleoplasm] (Bos taurus)

phospho-CDC6 [nucleoplasm] (Canis familiaris)

phospho-CDC6 [nucleoplasm] (Gallus gallus)

phospho-CDC6 [nucleoplasm] (Sus scrofa)

Modified Residues

Name

phosphorylated residue at unknown position

PsiMod Name

phosphorylated residue [MOD:00696]

PsiMod Definition

A protein modification that effectively replaces a hydrogen atom with a phosphate group.

Cross References

RefSeq

NP_001245.1

OpenTargets

ENSG00000094804

GeneCards

Q99741

HPA

ENSG00000094804-CDC6

Ensembl

ENST00000649662, ENSG00000094804, ENSP00000497345, ENSP00000209728, ENST00000209728

PRO

Q99741

Pharos - Targets

Q99741

Orphanet

19837

PDB

2CCI, 4I5N, 8HT7, 2CCH, 4I5L

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P53350 PLK1	4	PLK1 [nucleoplasm] (R-HSA-156720) p-T210-PLK1 [cytosol] (R-HSA-3000318) p-T210-PLK1 [nucleoplasm] (R-HSA-3002800) PLK1 [cytosol] (R-HSA-164603)	0.632	6
UniProt:Q9H211 CDT1	1	CDT1 [nucleoplasm] (R-HSA-68536)	0.609	3
UniProt:P38936 CDKN1A	5	p-T145-CDKN1A [cytosol] (R-HSA-198614) p-Y77-CDKN1A [cytosol] (R-HSA-8942601) CDKN1A [cytosol] (R-HSA-182512) CDKN1A [nucleoplasm] (R-HSA-182585) p-S130-CDKN1A [nucleoplasm] (R-HSA-187857)	0.571	2
UniProt:P28908 TNFRSF8	1	TNFRSF8 [plasma membrane] (R-HSA-5668758)	0.527	2
UniProt:Q9UHF4 IL20RA	1	IL20RA [plasma membrane] (R-HSA-448713)	0.527	2
UniProt:P37173 TGFBR2	9	TGFBR2 Y470D [plasma membrane] (R-HSA-3640905) TGFBR2 E526Q [plasma membrane] (R-HSA-3645770) TGFBR2 D522N [plasma membrane] (R-HSA-3640907) TGFBR2 R528H [plasma membrane] (R-HSA-3640894) TGFBR2 R528C [plasma membrane] (R-HSA-3640899) TGFBR2 K128Afs3 [cytosol] (R-HSA-3642173) TGFBR2 K128Sfs35 [cytosol] (R-HSA-3642166) NEDD8-K556,K567-TGFBR2 [plasma membrane] (R-HSA-4332222) TGFBR2 [plasma membrane] (R-HSA-170842)	0.527	2
UniProt:O14498 ISLR	2	ISLR [extracellular region] (R-HSA-8848919) ISLR [platelet alpha granule lumen] (R-HSA-8848912)	0.527	2
UniProt:Q9H8J5 MANS1			0.527	2
UniProt:Q9Y5F2 PCDBB			0.527	2
UniProt:Q86XD5 FAM131B	2	FAM131B(1-18)-BRAF(381-766) fusion [cytosol] (R-HSA-6802323) FAM131B(1-18)-p-BRAF(381-766) fusion [cytosol] (R-HSA-6802527)	0.527	2
UniProt:O60637 TSN3			0.527	2
UniProt:P06493 CDK1	11	CDK1 [endoplasmic reticulum membrane] (R-HSA-264424) p-Y4-CDK1 [cytosol] (R-HSA-9836187) p-T14,T161-CDK1 [nucleoplasm] (R-HSA-170078) p-T14-CDK1 [nucleoplasm] (R-HSA-170045) p-T14-CDK1 [cytosol] (R-HSA-170064) CDK1 [nucleoplasm] (R-HSA-68889) CDK1 [cytosol] (R-HSA-170075) p-T14,Y15,T161-CDK1 [cytosol] (R-HSA-170071) p-T161-CDK1 [cytosol] (R-HSA-157415) p-T14,Y15,T161-CDK1 [nucleoplasm] (R-HSA-170074) p-T161-CDK1 [nucleoplasm] (R-HSA-170066)	0.524	2
UniProt:O95801 TTC4			0.482	2

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