SORD tetramer oxidizes xylitol to D-xylulose

Stable Identifier
Reaction [transition]
Homo sapiens
xylitol + NAD+ => D-xylulose + NADH + H+
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Tetrameric sorbitol dehydrogenase (SORD tetramer) catalyzes the NAD-dependent oxidation of xylitol to form D-xylulose (Alvarez et al. 1993; Karlsson et al. 1989; Maret & Auld 1988; Pauly et al. 2003).

Literature References
PubMed ID Title Journal Year
3365415 Purification and characterization of human liver sorbitol dehydrogenase

Maret, W, Auld, DS

Biochemistry 1988
8487505 Membrane-bound sorbitol dehydrogenase in human red blood cells. Studies in normal subjects and in enzyme-deficient subjects with congenital cataracts

Vaca, G, Medina, C, Ibarra, B, Perea, J, Alvarez, A, Martínez, A, Bracamontes, M

J. Inherit. Metab. Dis. 1993
12962626 X-ray crystallographic and kinetic studies of human sorbitol dehydrogenase

Adams, PD, Cunningham, D, Kamath, A, Mcguire, D, Chrunyk, B, Madura, R, Lee, SE, Griffor, M, Pauly, TA, Beebe, DA, Ekstrom, JL, Wasilko, D, Subashi, T, Rath, VL, Oates, PJ, Mylari, BL, Watts, P

Structure 2003
2691249 Variability within mammalian sorbitol dehydrogenases. The primary structure of the human liver enzyme

Höög, JO, Karlsson, C, Jörnvall, H, Maret, W, Auld, DS

Eur. J. Biochem. 1989
Catalyst Activity

D-xylulose reductase activity of SORD tetramer [cytosol]

Orthologous Events
Cross References
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