Reactome | RAC1:GTP:FMNL1 binds profilin:G-actin

RAC1:GTP:FMNL1 binds profilin:G-actin

Stable Identifier

R-HSA-5665659

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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FMNL1, activated by binding to GTP-bound RAC1, binds actin-associated profilins PFN1 and PFN2 through the proline-rich FH1 domain of FMNL1 (Yayoshi-Yamamoto et al. 2000). The interaction with actin is achieved through the FH2 domain of FMNL1 (Romero et al. 2004, Kovar et al. 2006, Kuhn and Geyer 2014). FMNL1 and profilin-mediated reorganization of actin cytoskeleton is involved in the formation of lamellipodia, which regulates the motility of macrophages (Yayoshi-Yamamoto et al. 2000). FMNL1 was shown to regulate the structure of the Golgi complex, where different transcriptional isoforms of FMNL1 may play different roles (Colon-Franco et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
15507212	Formin is a processive motor that requires profilin to accelerate actin assembly and associated ATP hydrolysis Carlier, MF, Egile, C, Didry, D, Romero, S, Pantaloni, D, Le Clainche, C	Cell	2004
21868368	Dynamic remodeling of the actin cytoskeleton by FMNL1? is required for structural maintenance of the Golgi complex Gomez, TS, Billadeau, DD, Colón-Franco, JM	J. Cell. Sci.	2011
24914801	Formins as effector proteins of Rho GTPases Kühn, S, Geyer, M	Small GTPases	2014
16439214	Control of the assembly of ATP- and ADP-actin by formins and profilin Pollard, TD, Higgs, HN, Harris, ES, Mahaffy, R, Kovar, DR	Cell	2006
10958683	FRL, a novel formin-related protein, binds to Rac and regulates cell motility and survival of macrophages Yayoshi-Yamamoto, S, Taniuchi, I, Watanabe, T	Mol. Cell. Biol.	2000