SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin

Stable Identifier
R-HSA-5665802
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin
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SRGAP2 binds FMNL1 activated by RAC1:GTP by simultaneously interacting with RAC1 and FMNL1. SRGAP2 co-localizes with RAC1, FMNL1, profilin and actin at the plasma membrane after RAC1-mediated activation of FMNL1 (Mason et al. 2011).
Literature References
PubMed ID Title Journal Year
21148482 Bi-modal regulation of a formin by srGAP2

Higgs, HN, Heimsath, EG, Mason, FM, Soderling, SH

J. Biol. Chem. 2011
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Orthologous Events
SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Bos taurus)
SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Caenorhabditis elegans)
SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Canis familiaris)
SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Danio rerio)
SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Gallus gallus)
SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Mus musculus)
SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Rattus norvegicus)
SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Sus scrofa)
Authored
Orlic-Milacic, M  (2014-10-24)
Rivero Crespo, F  (2014-12-26)
Created
Orlic-Milacic, M  (2015-01-20)
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