RHOA:GTP:RTKN binds TAX1BP3

Stable Identifier
R-HSA-5666216
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
RHOA:GTP:RTKN binds TAX1BP3
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The PDZ domain of TAX1BP3 (TIP-1) binds the C-terminus of RTKN (rhotekin) associated with activated RHOA (RHOA:GTP). Binding of TAX1BP3 to the RHOA:GTP:RTKN complex stimulates SRF-mediated transcription through an unknown mechanism (Reynaud et al. 2000).
Literature References
PubMed ID Title Journal Year
10940294 The PDZ protein TIP-1 interacts with the Rho effector rhotekin and is involved in Rho signaling to the serum response element

Fabre, S, Reynaud, C, Jalinot, P

J. Biol. Chem. 2000
Participants
Input
Output
Participates
as an event of
Orthologous Events
RHOA:GTP:RTKN binds TAX1BP3 (Bos taurus)
RHOA:GTP:RTKN binds TAX1BP3 (Caenorhabditis elegans)
RHOA:GTP:RTKN binds TAX1BP3 (Canis familiaris)
RHOA:GTP:RTKN binds TAX1BP3 (Gallus gallus)
RHOA:GTP:RTKN binds TAX1BP3 (Mus musculus)
RHOA:GTP:RTKN binds TAX1BP3 (Rattus norvegicus)
RHOA:GTP:RTKN binds TAX1BP3 (Sus scrofa)
Authored
Orlic-Milacic, M  (2014-10-24)
Rivero Crespo, F  (2014-12-26)
Created
Orlic-Milacic, M  (2015-01-22)
Cite Us!