Reactome | RHOA:GTP:RTKN binds TAX1BP3

RHOA:GTP:RTKN binds TAX1BP3

Stable Identifier

R-HSA-5666216

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

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The PDZ domain of TAX1BP3 (TIP-1) binds the C-terminus of RTKN (rhotekin) associated with activated RHOA (RHOA:GTP). Binding of TAX1BP3 to the RHOA:GTP:RTKN complex stimulates SRF-mediated transcription through an unknown mechanism (Reynaud et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
10940294	The PDZ protein TIP-1 interacts with the Rho effector rhotekin and is involved in Rho signaling to the serum response element Fabre, S, Reynaud, C, Jalinot, P	J. Biol. Chem.	2000