Reactome | TAX1BP3 [cytosol]

TAX1BP3 [cytosol]

Stable Identifier

R-HSA-5666217

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Tax1-binding protein 3, TIP1, TIP-1

Locations in the PathwayBrowser for interactor UniProt:O75914 PAK3

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Signal Transduction (Homo sapiens)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase Effectors (Homo sapiens)
      - RHO GTPases Activate Rhotekin and Rhophilins (Homo sapiens)
        
        RHOA:GTP:RTKN binds TAX1BP3 (Homo sapiens)
        
        TAX1BP3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O14907 TAX1BP3

Gene Names

TAX1BP3, TIP1

Chain

initiator methionine:1, chain:2-124

Reference Genes

BioGPS Gene:30851 TAX1BP3

COSMIC (genes):TAX1BP3 TAX1BP3

CTD Gene:30851 TAX1BP3

dbSNP Gene:30851 TAX1BP3

ENSEMBL:ENSG00000213977 TAX1BP3

HGNC:30684 TAX1BP3

KEGG:hsa:30851 TAX1BP3

Monarch:30851 TAX1BP3

NCBI Gene:30851 TAX1BP3

OMIM:616476 AGBL4

UCSC:O14907 TAX1BP3

Reference Transcript

Other Identifiers

11715876_at

16839769

209154_PM_at

209154_at

215464_PM_s_at

215464_s_at

30851

3741530

3741531

3741532

3741535

3741537

3741538

3741545

3741546

39416_at

8011407

89919_s_at

A_23_P38468

GE79004

GE85953

GO:0001650

GO:0005515

GO:0005634

GO:0005737

GO:0005829

GO:0005856

GO:0005886

GO:0007266

GO:0008013

GO:0008285

GO:0015629

GO:0016020

GO:0016055

GO:0030178

GO:0032489

GO:0070062

GO:2000009

HMNXSV003040735

Hs.12956.1.S1_3p_a_at

ILMN_1803392

PH_hs_0001245

PH_hs_0031003

TC17002884.hg

U90913_at

g12005281_3p_at

g12005281_3p_x_at

p33681

Participates

as a component of

RHOA:GTP:RTKN:TAX1BP3 [plasma membrane] (Homo sapiens)

as an input of

RHOA:GTP:RTKN binds TAX1BP3 (Homo sapiens)

Cross References

RefSeq

NP_001191627.1, NP_055419.1

OpenTargets

ENSG00000213977

ENSEMBL

ENSP00000225525, ENST00000225525, ENSG00000213977

HPA

ENSG00000213977-TAX1BP3

GeneCards

TAX1BP3

PRO

O14907

Pharos - Targets

O14907

GlyGen

O14907

PDB

2VZ5, 2L4T, 2L4S, 3GJ9, 3SFJ, 4NNM, 4NNL, 2KG2, 4E3B

Interactors (28)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) CTNNB1 [nucleoplasm] (R-HSA-3451168) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1(1-115) [cytosol] (R-HSA-202930) CTNNB1(116-376) [cytosol] (R-HSA-202950) CTNNB1 [plasma membrane] (R-HSA-9038440) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) p-Y-CTNNB1 [cytosol] (R-HSA-8876940) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926)	0.764	6
UniProt:P25054 APC	20	APC R213* [cytosol] (R-HSA-9666924) APC C1410* [cytosol] (R-HSA-9666925) APC K1310* [cytosol] (R-HSA-9666926) APC R499* [cytosol] (R-HSA-9666927) APC R1450* [cytosol] (R-HSA-5251499) APC G1357* [cytosol] (R-HSA-9666940) APC L1488* [cytosol] (R-HSA-9666941) APC S1400* [cytosol] (R-HSA-9666942) APC S1346* [cytosol] (R-HSA-9666943) APC R405* [cytosol] (R-HSA-9666936) APC S1281* [cytosol] (R-HSA-9666937) APC E1573* [cytosol] (R-HSA-9666938) APC R805* [cytosol] (R-HSA-9666939) APC R1386* [cytosol] (R-HSA-9666932) APC S1327* [cytosol] (R-HSA-9666933) APC E1209* [cytosol] (R-HSA-9666934) APC Q1469* [cytosol] (R-HSA-9666935) APC R564* [cytosol] (R-HSA-9666928) APC E1536* [cytosol] (R-HSA-9666929) APC G1288* [cytosol] (R-HSA-9666930)	0.688	5
UniProt:O00192 ARVC			0.688	5
UniProt:Q9HCD6 TANC2			0.688	5
UniProt:Q99569 PKP4	2	PKP4 [plasma membrane] (R-HSA-6814401) PKP4 [cornified envelope] (R-HSA-8847721)	0.688	5
UniProt:Q9C0D5 TANC1			0.688	4
UniProt:O14578 CIT	1	CIT [cytosol] (R-HSA-1629806)	0.688	5
UniProt:Q9BST9 RTKN	1	RTKN [cytosol] (R-HSA-5666184)	0.688	5
UniProt:P03126 VE6			0.658	3
UniProt:P06463 VE6			0.647	3
UniProt:Q3KP66 INAVA			0.643	4
UniProt:Q9UDY2 TJP2	4	TJP2 [nucleoplasm] (R-HSA-2064410) TJP2 [cytosol] (R-HSA-2064412) TJP2(?-?) [plasma membrane] (R-HSA-351897) TJP2 [plasma membrane] (R-HSA-351862)	0.59	2
UniProt:Q9UQB3 CTND2			0.59	2
UniProt:Q96D59 RN183			0.556	3
UniProt:Q8WUF5 PPP1R13L	1	PPP1R13L [nucleoplasm] (R-HSA-6799738)	0.527	4
UniProt:O60716 CTNND1	2	CTNND1 [plasma membrane] (R-HSA-418996) p-Y-CTNND1 [plasma membrane] (R-HSA-9934835)	0.527	2
UniProt:Q13177 PAK2	11	p-S141,T402-PAK2 [cytosol] (R-HSA-399824) PAK2 [cytosol] (R-HSA-211604) p-5S-PAK2 [cytosol] (R-HSA-211609) PAK2(213-524) [cytosol] (R-HSA-211653) p-5S-PAK2(2-212) [cytosol] (R-HSA-211588) p-T402-PAK2(213-524) [cytosol] (R-HSA-211654) p-T402-PAK2(213-524) [nucleoplasm] (R-HSA-211709) K48polyUb-p-T402-PAK-2p43 [cytosol] (R-HSA-3095873) p-Y130,S141,T402-PAK2 [cytosol] (R-HSA-5218705) PAK2(1-524) [plasma membrane] (R-HSA-164946) p-S141,T402-PAK2 [plasma membrane] (R-HSA-5096524)	0.527	4
UniProt:Q14155 ARHGEF7	1	ARHGEF7 [cytosol] (R-HSA-430346)	0.527	4
UniProt:Q13153 PAK1	5	p-S144,T423-PAK1 [cytosol] (R-HSA-399819) PAK1 [cytosol] (R-HSA-162629) Active PAK1 [cytosol] (R-HSA-8964622) p-S144,T423-PAK1 [plasma membrane] (R-HSA-3928472) PAK1 [plasma membrane] (R-HSA-3928409)	0.527	4
UniProt:O75914 PAK3	3	PAK3 [cytosol] (R-HSA-428457) p-S154,T436-PAK3 [cytosol] (R-HSA-5357471) p-S154,T436-PAK3 [plasma membrane] (R-HSA-3928479)	0.527	3
UniProt:Q9Y2X7 GIT1	2	GIT1 [cytosol] (R-HSA-430326) p-Y383-GIT1 [cytosol] (R-HSA-3928463)	0.527	4
UniProt:Q9P2Q2 FRM4A			0.527	3
UniProt:P26232 CTNNA2	1	CTNNA2 [cytosol] (R-HSA-448798)	0.527	4
UniProt:Q99622 C10			0.527	4
UniProt:Q14161 GIT2	1	GIT2 [cytosol] (R-HSA-446034)	0.527	4
UniProt:P19022 CDH2	3	p-CDH2 [endoplasmic reticulum lumen] (R-HSA-8956899) CDH2 [endoplasmic reticulum lumen] (R-HSA-8956761) CDH2 [plasma membrane] (R-HSA-191429)	0.527	3
UniProt:P27228 VE6			0.525	2
UniProt:P03409 TAX			0.525	2

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