Reactome | CD70 [plasma membrane]

CD70 [plasma membrane]

Stable Identifier

R-HSA-5667139

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

CD70 antigen, CD70_HUMAN

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - TNFR2 non-canonical NF-kB pathway (Homo sapiens)
    - TNFs bind their physiological receptors (Homo sapiens)
      - CD70 binds CD27 (Homo sapiens)
        
        CD27:CD70 homotrimer [plasma membrane] (Homo sapiens)
        
        CD70 homotrimer [plasma membrane] (Homo sapiens)
        
        CD70 [plasma membrane] (Homo sapiens)
        
        CD70 homotrimer [plasma membrane] (Homo sapiens)
        
        CD70 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P32970 CD70

Gene Names

CD70, CD27L, CD27LG, TNFSF7

Chain

chain:1-193

Reference Genes

BioGPS Gene:970 CD70

COSMIC (genes):CD70 CD70

CTD Gene:970 CD70

dbSNP Gene:970 CD70

ENSEMBL:ENSG00000125726 CD70

HGNC:11937 CD70

KEGG:hsa:970 CD70

Monarch:970 CD70

NCBI Gene:970 CD70

OMIM:602840 CD70

UCSC:P32970 CD70

Reference Transcript

Other Identifiers

11731682_at

11761421_at

16867766

206508_PM_at

206508_at

34054_at

3847990

3847994

3847995

3847996

3847997

3847998

3847999

3848000

3848001

3848002

8033241

970

A_23_P119202

GE79054

GO:0002376

GO:0002456

GO:0005102

GO:0005164

GO:0005515

GO:0005886

GO:0006955

GO:0007154

GO:0016020

GO:0019724

GO:0023052

GO:0033209

GO:0042098

GO:0042100

GO:0042102

GO:0042110

GO:0043226

GO:0048018

GO:0070062

GO:0090717

GO:0097191

GO:0098772

GO:0160162

HMNXSV003028982

ILMN_1760247

L08096_s_at

PH_hs_0005580

TC19001101.hg

g4507604_3p_at

Participates

as a component of

CD70 homotrimer [plasma membrane] (Homo sapiens)

Inferred To

CD70 [plasma membrane] (Bos taurus)

CD70 [plasma membrane] (Canis familiaris)

CD70 [plasma membrane] (Sus scrofa)

Cd70 [plasma membrane] (Mus musculus)

Cross References

ENSEMBL

ENST00000423145, ENSG00000125726, ENST00000245903, ENSP00000245903, ENSP00000395294

OpenTargets

ENSG00000125726

GeneCards

CD70

HPA

ENSG00000125726-CD70

PRO

P32970

Pharos - Targets

P32970

GlyGen

P32970

Orphanet

CD70

PDB

7KX0

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q969Z0 TBRG4	1	TBRG4 [mitochondrial matrix] (R-HSA-9837166)	0.527	3
UniProt:Q8TAG9 EXOC6	2	EXOC6 [plasma membrane] (R-HSA-265041) EXOC6 [cytosol] (R-HSA-5623384)	0.527	2
UniProt:Q9H5Q4 TFB2M	1	TFB2M [mitochondrial matrix] (R-HSA-163272)	0.527	3
UniProt:Q9NUQ2 AGPAT5	2	AGPAT5 [mitochondrial outer membrane] (R-HSA-1500585) AGPAT5 [endoplasmic reticulum membrane] (R-HSA-61811)	0.527	3
UniProt:Q9NWZ5 UCKL1	1	UCKL1 [cytosol] (R-HSA-8954322)	0.527	2
UniProt:O15431 SLC31A1	1	SLC31A1 [plasma membrane] (R-HSA-437299)	0.527	2
UniProt:Q5JTZ9 AARS2	1	AARS2 [mitochondrial matrix] (R-HSA-379653)	0.527	2
UniProt:O15287 FANCG	2	FANCG [cytosol] (R-HSA-420788) FANCG [nucleoplasm] (R-HSA-419532)	0.527	3
UniProt:Q96I59 NARS2	1	NARS2 [mitochondrial matrix] (R-HSA-379585)	0.527	2
UniProt:Q8TAD4 SLC30A5	2	SLC30A5 [Golgi membrane] (R-HSA-9817559) SLC30A5 [secretory granule membrane] (R-HSA-437105)	0.527	2
UniProt:Q9H8H0 NOL11	1	NOL11 [nucleoplasm] (R-HSA-6790684)	0.527	3
UniProt:O43913 ORC5	1	ORC5 [nucleoplasm] (R-HSA-68516)	0.527	2
UniProt:P26842 CD27	1	CD27 [plasma membrane] (R-HSA-5666994)	0.527	2
UniProt:P24468 NR2F2	1	NR2F2 [nucleoplasm] (R-HSA-1183002)	0.527	2
UniProt:P36507 MAP2K2	12	p-S222,S226-MAP2K2 [cytosol] (R-HSA-169292) MAP2K2 [cytosol] (R-HSA-59504) p-S,T-MAP2K2 [cytosol] (R-HSA-109848) MAP2K2 N126D [cytosol] (R-HSA-9652079) MAP2K2 L46F [cytosol] (R-HSA-9652076) MAP2K2 F57C [cytosol] (R-HSA-9652073) MAP2K2 Y134C [cytosol] (R-HSA-9652089) MAP2K2 V35M [cytosol] (R-HSA-9652086) MAP2K2 P128Q [cytosol] (R-HSA-9652082) MAP2K2 C125S [cytosol] (R-HSA-9652070) MAP2K2(11-400) [cytosol] (R-HSA-5211337) MAP2K2(1-10) [cytosol] (R-HSA-5211334)	0.527	2
UniProt:Q13315 ATM	5	ATM [cytosol] (R-HSA-9665171) ATM [peroxisomal matrix] (R-HSA-9665169) p-S1981,Ac-K3016-ATM [nucleoplasm] (R-HSA-5693527) ATM [nucleoplasm] (R-HSA-69484) Ac-K3016-ATM [nucleoplasm] (R-HSA-5682043)	0.527	2

Cite Us!