Reactome | TNFSF8 [plasma membrane]

TNFSF8 [plasma membrane]

Stable Identifier

R-HSA-5667148

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Tumor necrosis factor ligand superfamily member 8, TNFL8_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q13535 ATR

Expand all

External Reference Information

External Reference

UniProt:P32971 TNFSF8

Gene Names

TNFSF8, CD30L, CD30LG

Chain

chain:1-234

Reference Genes

BioGPS Gene:944 TNFSF8

COSMIC (genes):TNFSF8 TNFSF8

CTD Gene:944 TNFSF8

dbSNP Gene:944 TNFSF8

ENSEMBL:ENSG00000106952 TNFSF8

ENSEMBL_homo_sapiens_GENE:ENSG00000106952.8 TNFSF8

HGNC:11938 TNFSF8

KEGG Gene (Homo sapiens):944 TNFSF8

Monarch:944 TNFSF8

NCBI Gene:944 TNFSF8

OMIM:603875 TNFSF8

Reference Transcript

RefSeq:NM_001244.3 TNFSF8

Other Identifiers

11737777_at

11737778_at

17097653

207216_PM_at

207216_at

235735_PM_at

235735_at

3222147

3222148

3222149

3222150

3222151

3222152

3222153

3222159

3222161

3222162

3222163

33012_at

49886_at

8163629

87425_at

944

A_23_P169257

GE591251

GE631622

GE80298

GO:0002376

GO:0005102

GO:0005125

GO:0005164

GO:0005515

GO:0005576

GO:0005615

GO:0005886

GO:0006351

GO:0006355

GO:0006955

GO:0007154

GO:0007165

GO:0007267

GO:0016020

GO:0023052

GO:0030154

GO:0042129

GO:0043374

GO:0045944

GO:0048018

GO:0048856

GO:0050830

GO:0098542

GO:0098772

HMNXSV003049131

Hs.101370.0.A1_3p_at

ILMN_1761778

L09753_at

PH_hs_0022857

TC09001516.hg

g4507606_3p_at

Participates

as a component of

TNFSF8:TNFRSF8 [plasma membrane] (Homo sapiens)

as an input of

TNFSF8 binds TNFRSF8 (Homo sapiens)

Inferred To

Tnfsf8 [plasma membrane] (Mus musculus)

Tnfsf8 [plasma membrane] (Rattus norvegicus)

TNFSF8 [plasma membrane] (Bos taurus)

TNFSF8 [plasma membrane] (Canis familiaris)

TNFSF8 [plasma membrane] (Gallus gallus)

TNFSF8 [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_001235.1

OpenTargets

ENSG00000106952

HPA

ENSG00000106952-TNFSF8

GeneCards

P32971

Ensembl

ENST00000223795, ENSP00000223795, ENSG00000106952

PRO

P32971

Pharos - Targets

P32971

Interactors (29)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q07325 CXCL9	1	CXCL9 [extracellular region] (R-HSA-373856)	0.556	3
UniProt:O95393 BMP10	2	BMP10(22-424) [extracellular region] (R-HSA-2396409) BMP10 [extracellular region] (R-HSA-8858374)	0.556	3
UniProt:Q9BRY0 SLC39A3	1	SLC39A3 [plasma membrane] (R-HSA-442426)	0.527	3
UniProt:Q8WUJ1 NEUFC			0.527	3
UniProt:Q6UX07 DHR13			0.527	3
UniProt:Q8NHS3 MFSD8			0.527	2
UniProt:Q14118 DAG1	10	GalNAc-GlcNAc-Man6P-DAG1 [endoplasmic reticulum lumen] (R-HSA-8931659) GlcNAc,1,2-Man-DAG1 [Golgi lumen] (R-HSA-5617087) Man-DAG1 [Golgi lumen] (R-HSA-8931888) GalNAc-GlcNAc-Man-DAG1 [endoplasmic reticulum lumen] (R-HSA-8931656) GlcNAc-Man-DAG1 [endoplasmic reticulum lumen] (R-HSA-8931673) Man-DAG1 [endoplasmic reticulum lumen] (R-HSA-5615647) DAG1(30-653) [endoplasmic reticulum lumen] (R-HSA-8931890) DAG1(30-653) [cytosol] (R-HSA-5615641) DAG1(30-653) [extracellular region] (R-HSA-2328152) DAG1(654-895) [plasma membrane] (R-HSA-2328154)	0.527	3
UniProt:Q13535 ATR	1	ATR [nucleoplasm] (R-HSA-912443)	0.527	3
UniProt:P02042 HBD	1	HBD [cytosol] (R-HSA-1008218)	0.527	3
UniProt:P12259 F5	15	factor V [platelet alpha granule lumen] (R-HSA-141766) F5(535-737) [extracellular region] (R-HSA-5605103) F5(335-534) [extracellular region] (R-HSA-5605102) F5(29-334) [extracellular region] (R-HSA-5605101) F5(29-534) [extracellular region] (R-HSA-5605104) factor V activation peptide [extracellular region] (R-HSA-140787) factor V [extracellular region] (R-HSA-140697) factor Va heavy chain [extracellular region] (R-HSA-140691) factor Va light chain [extracellular region] (R-HSA-140690) factor Va heavy chain [plasma membrane] (R-HSA-140653) Factor V precursor [endoplasmic reticulum lumen] (R-HSA-5689447) p-Factor V precursor [endoplasmic reticulum lumen] (R-HSA-8956960) Factor V precursor [COPII-coated ER to Golgi transport vesicle] (R-HSA-5689792) Factor V precursor [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5689793) factor Va light chain [plasma membrane] (R-HSA-140660)	0.527	3
UniProt:Q9BZM6 ULBP1	1	ULBP1 [plasma membrane] (R-HSA-199509)	0.527	3
UniProt:Q15768 EFNB3	2	p-Y318,Y323,Y337-EFNB3 [plasma membrane] (R-HSA-3928388) EFNB3 [plasma membrane] (R-HSA-2682319)	0.527	2
UniProt:Q9C0C4 SEM4C			0.527	2
UniProt:Q9UBI1 COMMD3	4	COMMD3 [nucleoplasm] (R-HSA-8955108) COMMD3 [cytosol] (R-HSA-8955113) COMMD3 [extracellular region] (R-HSA-6806501) COMMD3 [ficolin-1-rich granule lumen] (R-HSA-6801405)	0.527	3
UniProt:Q9BZM5 ULBP2	2	cleaved GPI-ULBP2 [extracellular region] (R-HSA-8941023) GPI-ULBP2 [plasma membrane] (R-HSA-8940750)	0.527	2
UniProt:Q9BZM4 ULBP3	1	ULBP3 [plasma membrane] (R-HSA-198076)	0.527	3
UniProt:Q9NZ53 PODXL2	2	OSulf-Y97,118-PODXL2 [Golgi lumen] (R-HSA-8954273) PODXL2 [Golgi lumen] (R-HSA-8954248)	0.527	2
UniProt:P17706 PTPN2	3	p-PTPN2 [cytosol] (R-HSA-9836510) PTPN2 [nucleoplasm] (R-HSA-9008891) PTPN2 [cytosol] (R-HSA-997292)	0.527	2
UniProt:P51956 NEK3			0.527	2
UniProt:P41273 TNFSF9	1	TNFSF9 [plasma membrane] (R-HSA-5667144)	0.527	3
UniProt:Q96DA2 RAB39B	3	GGC-RAB39B [Golgi membrane] (R-HSA-8877796) GGC-RAB39B [cytosol] (R-HSA-8874006) RAB39B [cytosol] (R-HSA-8873679)	0.527	2
UniProt:Q8N441 FGFRL1	1	FGFRL1 [plasma membrane] (R-HSA-197650)	0.527	2
UniProt:P69905 HBA1	4	CO-H+-HBA1 [cytosol] (R-HSA-1237026) HBA1 [cytosol] (R-HSA-1008268) HBA1 [endocytic vesicle lumen] (R-HSA-2230966) HBA1 [extracellular region] (R-HSA-2168862)	0.527	3
UniProt:Q16625 OCLN	4	OCLN [cell junction] (R-HSA-2160944) OCLN(1-320) [plasma membrane] (R-HSA-351854) OCLN(321-522) [plasma membrane] (R-HSA-351873) OCLN [plasma membrane] (R-HSA-351846)	0.527	3
UniProt:Q8N8Z6 DCBD1			0.527	2
UniProt:P98172 EFNB1	2	p-Y324,Y329,Y343-EFNB1 [plasma membrane] (R-HSA-3928412) EFNB1 [plasma membrane] (R-HSA-2682327)	0.527	3
UniProt:O14657 TOR1B	1	TOR1B [cytosol] (R-HSA-8862861)	0.527	3
UniProt:O75879 GATB			0.527	2
UniProt:Q96BW9 TAM41			0.527	2

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