Reactome | TNFSF14 [plasma membrane]

TNFSF14 [plasma membrane]

Stable Identifier

R-HSA-5667149

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Tumor necrosis factor ligand superfamily member 14, TNF14_HUMAN

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Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - TNFR2 non-canonical NF-kB pathway (Homo sapiens)
    - K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Homo sapiens)
      - TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
        
        TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
        
        3xLTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
        
        LTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
        
        lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
        
        TNFSF14 trimer [plasma membrane] (Homo sapiens)
        
        TNFSF14 [plasma membrane] (Homo sapiens)
      - TNFSF:TNFRSF heterotrimer:TRAF2:K63polyUb-cIAP1,2:K48polyUb-TRAF3:NIK [plasma membrane] (Homo sapiens)
        
        TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
        
        3xLTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
        
        LTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
        
        lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
        
        TNFSF14 trimer [plasma membrane] (Homo sapiens)
        
        TNFSF14 [plasma membrane] (Homo sapiens)
    - Protesomal degradation of K48polyUb-TRAF3 (Homo sapiens)
      - TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
        
        3xLTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
        
        LTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
        
        lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
        
        TNFSF14 trimer [plasma membrane] (Homo sapiens)
        
        TNFSF14 [plasma membrane] (Homo sapiens)
      - TNFSF:TNFRSF heterotrimer:TRAF2:K63polyUb-cIAP1,2:K48polyUb-TRAF3:NIK [plasma membrane] (Homo sapiens)
        
        TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
        
        3xLTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
        
        LTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
        
        lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
        
        TNFSF14 trimer [plasma membrane] (Homo sapiens)
        
        TNFSF14 [plasma membrane] (Homo sapiens)
    - TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway (Homo sapiens)
      - 2xLTBR binds LTBR:lymphotoxin,TNFSF14 trimer (Homo sapiens)
        
        3xLTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
        
        LTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
        
        lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
        
        TNFSF14 trimer [plasma membrane] (Homo sapiens)
        
        TNFSF14 [plasma membrane] (Homo sapiens)
        
        LTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
        
        lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
        
        TNFSF14 trimer [plasma membrane] (Homo sapiens)
        
        TNFSF14 [plasma membrane] (Homo sapiens)
      - LA,TNFSF14 binds LTBR (Homo sapiens)
        
        LTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
        
        lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
        
        TNFSF14 trimer [plasma membrane] (Homo sapiens)
        
        TNFSF14 [plasma membrane] (Homo sapiens)
        
        lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
        
        TNFSF14 trimer [plasma membrane] (Homo sapiens)
        
        TNFSF14 [plasma membrane] (Homo sapiens)
      - TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR (Homo sapiens)
        
        3xLTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
        
        LTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
        
        lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
        
        TNFSF14 trimer [plasma membrane] (Homo sapiens)
        
        TNFSF14 [plasma membrane] (Homo sapiens)
        
        3xLTBR:lymphotoxin,TNFSF14 trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
        
        3xLTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
        
        LTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
        
        lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
        
        TNFSF14 trimer [plasma membrane] (Homo sapiens)
        
        TNFSF14 [plasma membrane] (Homo sapiens)
    - TNFs bind their physiological receptors (Homo sapiens)
      - TNFRSF6B binds TNFSF6,14,15 (Homo sapiens)
        
        TNFRSF6B:TNFSF6,14,15 [plasma membrane] (Homo sapiens)
        
        TNFSF6,14,15 [plasma membrane] (Homo sapiens)
        
        TNFSF14 [plasma membrane] (Homo sapiens)
        
        TNFSF6,14,15 [plasma membrane] (Homo sapiens)
        
        TNFSF14 [plasma membrane] (Homo sapiens)
    - TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Homo sapiens)
      - Non-canonical NF-kB initiating TNFRSF memebers [plasma membrane] (Homo sapiens)
        
        3xLTBR:lymphotoxin,TNFSF14 trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
        
        3xLTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
        
        LTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
        
        lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
        
        TNFSF14 trimer [plasma membrane] (Homo sapiens)
        
        TNFSF14 [plasma membrane] (Homo sapiens)
      - TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
        
        TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
        
        3xLTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
        
        LTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
        
        lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
        
        TNFSF14 trimer [plasma membrane] (Homo sapiens)
        
        TNFSF14 [plasma membrane] (Homo sapiens)
    - cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Homo sapiens)
      - TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
        
        TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
        
        3xLTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
        
        LTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
        
        lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
        
        TNFSF14 trimer [plasma membrane] (Homo sapiens)
        
        TNFSF14 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:O43557 TNFSF14

Gene Names

TNFSF14, HVEML, LIGHT, UNQ391/PRO726

Chain

chain:1-240, chain:83-240

Reference Genes

BioGPS Gene:8740 TNFSF14

COSMIC (genes):TNFSF14 TNFSF14

CTD Gene:8740 TNFSF14

dbSNP Gene:8740 TNFSF14

ENSEMBL:ENSG00000125735 TNFSF14

ENSEMBL_homo_sapiens_GENE:ENSG00000125735.11 TNFSF14

HGNC:11930 TNFSF14

KEGG Gene (Homo sapiens):8740 TNFSF14

Monarch:8740 TNFSF14

NCBI Gene:8740 TNFSF14

OMIM:604520 TNFSF14

UCSC:O43557 TNFSF14

Reference Transcript

Other Identifiers

11738883_x_at

11741290_a_at

16867775

207907_3p_at

207907_PM_at

207907_at

233935_PM_at

233935_at

31742_at

3848015

3848019

3848021

3848022

3848023

3848024

3848025

3848026

3848027

3848028

3848029

3848032

3848033

3848034

3848035

3848036

8033248

8740

A_24_P237036

GE54584

GE775468

GO:0002376

GO:0005102

GO:0005125

GO:0005164

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0005886

GO:0006915

GO:0006955

GO:0007154

GO:0007155

GO:0007165

GO:0010818

GO:0010820

GO:0012501

GO:0016020

GO:0023052

GO:0030154

GO:0031295

GO:0042098

GO:0042110

GO:0042802

GO:0043027

GO:0043029

GO:0045663

GO:0048018

GO:0048856

GO:0048870

GO:0071260

GO:0098772

GO:1901224

GO:1901741

HMNXSV003054324

Hs.242868.0.S1_3p_at

ILMN_1655414

ILMN_1661343

ILMN_2363392

PH_hs_0007592

TC19001102.hg

TC19002306.hg

g4507600_3p_x_at

Participates

as a member of

TNFSF6,14,15 [plasma membrane] (Homo sapiens)

as a component of

TNFSF14 trimer [plasma membrane] (Homo sapiens)

Inferred To

tnfsf14 [plasma membrane] (Xenopus tropicalis)

Tnfsf14 [plasma membrane] (Mus musculus)

Tnfsf14 [plasma membrane] (Rattus norvegicus)

TNFSF14 [plasma membrane] (Bos taurus)

TNFSF14 [plasma membrane] (Canis familiaris)

TNFSF14 [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_003798.2, NP_742011.2, XP_016882906.1

OpenTargets

ENSG00000125735

HPA

ENSG00000125735-TNFSF14

GeneCards

O43557

Ensembl

ENSP00000502837, ENST00000599359, ENST00000245912, ENSG00000125735, ENSP00000245912, ENSP00000469049, ENST00000675206

PRO

O43557

Pharos - Targets

O43557

PDB

4KG8, 4KGG, 4KGQ, 4J6G, 4RSU, 7MSG, 4EN0

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q92956 TNFRSF14	1	TNFRSF14 [plasma membrane] (R-HSA-198101)	0.743	5
UniProt:P17152 TMEM11	1	TMEM11 [mitochondrial inner membrane] (R-HSA-8949578)	0.556	3
UniProt:Q15848 ADIPOQ	1	ADIPOQ [extracellular region] (R-HSA-1183052)	0.556	3
UniProt:Q15436 SEC23A	4	p-S738,T744 SEC23A [cytosol] (R-HSA-5685740) SEC23A [ER to Golgi transport vesicle membrane] (R-HSA-204024) SEC23A [cytosol] (R-HSA-203972) SEC23A [endoplasmic reticulum membrane] (R-HSA-203976)	0.556	3
UniProt:Q8N2H4 SYS1	1	SYS1 [trans-Golgi network membrane] (R-HSA-6813921)	0.556	3
UniProt:P36941 LTBR	1	LTBR [plasma membrane] (R-HSA-5668750)	0.524	3
UniProt:O95407 TNFRSF6B	1	TNFRSF6B [extracellular region] (R-HSA-5675950)	0.524	2
UniProt:P50284 Ltbr	2	Ltbr [plasma membrane] (R-MMU-5668809) Ltbr [plasma membrane] (R-MMU-5668750)	0.524	2

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