Reactome | EDA [plasma membrane]

EDA [plasma membrane]

Stable Identifier

R-HSA-5667156

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Ectodysplasin-A, EDA_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q92838 EDA

Gene Names

EDA, ED1, EDA2

Chain

chain:1-391, chain:160-391

Reference Genes

BioGPS Gene:1896 EDA

COSMIC (genes):EDA EDA

CTD Gene:1896 EDA

dbSNP Gene:1896 EDA

ENSEMBL:ENSG00000158813.18 EDA

HGNC:3157 EDA

KEGG Gene (Homo sapiens):1896 EDA

Monarch:1896 EDA

NCBI Gene:1896 EDA

OMIM:300451 EDA

UCSC:Q92838 EDA

Reference Transcript

Other Identifiers

0106860136

11728157_at

11728158_at

11735891_a_at

11738669_at

11742331_x_at

17104387

1896

206217_PM_at

206217_at

211128_PM_at

211128_at

211131_PM_s_at

211131_s_at

37139_at

37140_s_at

3980381

3980382

3980383

3980384

3980385

3980386

3980387

3980388

3980395

3980396

3980415

3980416

3980418

3980419

3980429

3980430

3980431

3980433

3980434

3980436

3980437

3980441

3980443

8168062

A_14_P129658

A_23_P34045

A_24_P100419

A_33_P3303572

GE58253

GO:0001942

GO:0002376

GO:0005102

GO:0005123

GO:0005164

GO:0005515

GO:0005576

GO:0005581

GO:0005615

GO:0005622

GO:0005737

GO:0005783

GO:0005789

GO:0005811

GO:0005856

GO:0005886

GO:0005887

GO:0006351

GO:0006355

GO:0006955

GO:0007154

GO:0007155

GO:0007160

GO:0010467

GO:0010628

GO:0016020

GO:0016021

GO:0023052

GO:0030154

GO:0032991

GO:0038177

GO:0042475

GO:0043123

GO:0043226

GO:0043231

GO:0043473

GO:0043588

GO:0045177

GO:0048018

GO:0048513

GO:0048856

GO:0051092

GO:0060070

GO:0060662

GO:0060789

GO:0061153

GO:0090263

GO:0098772

GO:1901224

HMNXSV003039437

ILMN_1671633

ILMN_1684000

ILMN_1709975

ILMN_1791250

ILMN_2381655

PH_hs_0031501

U59228_at

g3779249_3p_at

g3779253_3p_a_at

g4503448_3p_at

Participates

as a component of

EDA:EDAR [plasma membrane] (Homo sapiens)

as an input of

EDA binds EDAR (Homo sapiens)

Inferred To

EDA [plasma membrane] (Bos taurus)

EDA [plasma membrane] (Canis familiaris)

EDA [plasma membrane] (Danio rerio)

EDA [plasma membrane] (Gallus gallus)

EDA [plasma membrane] (Sus scrofa)

egr [plasma membrane] (Drosophila melanogaster)

Eda [plasma membrane] (Mus musculus)

Eda [plasma membrane] (Rattus norvegicus)

eda [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001005610.2, NP_001005612.2, NP_001005613.1, NP_001005609.1, NP_001390.1

OpenTargets

ENSG00000158813

GeneCards

Q92838

HPA

ENSG00000158813-EDA

Ensembl

ENSG00000158813, ENST00000524573, ENSP00000363680, ENSP00000363681, ENST00000338901, ENSP00000434195, ENSP00000434861, ENST00000374552, ENSP00000340611, ENST00000374553, ENSP00000432585, ENST00000525810, ENST00000527388

PRO

Q92838

Pharos - Targets

Q92838

Orphanet

15908

PDB

1RJ7, 1RJ8

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P26678 PLN	2	p-S16-PLN [sarcoplasmic reticulum membrane] (R-HSA-5578813) PLN [sarcoplasmic reticulum membrane] (R-HSA-5490319)	0.886	11
UniProt:Q6P499 NIPAL3	1	NIPAL3 [plasma membrane] (R-HSA-5215974)	0.781	8
UniProt:Q96IW7 SEC22A	3	SEC22A [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688562) SEC22A [ER to Golgi transport vesicle membrane] (R-HSA-5688560) SEC22A [endoplasmic reticulum membrane] (R-HSA-5216111)	0.781	7
UniProt:P54852 EMP3			0.781	7
UniProt:P21145 MAL			0.781	7
UniProt:Q96F15 GIMA5			0.718	6
UniProt:Q9UPQ8 DOLK	6	DOLK [endoplasmic reticulum membrane] (R-HSA-449274) DOLK M1I [endoplasmic reticulum membrane] (R-HSA-4755593) DOLK H408D [endoplasmic reticulum membrane] (R-HSA-4755548) DOLK C99S [endoplasmic reticulum membrane] (R-HSA-4755602) DOLK W304C [endoplasmic reticulum membrane] (R-HSA-4755557) DOLK Y441S [endoplasmic reticulum membrane] (R-HSA-4755590)	0.718	6
UniProt:P49447 CY561			0.718	6
UniProt:O95214 LERL1			0.666	4
UniProt:P27449 ATP6V0C	7	ATP6V0C [lysosomal membrane] (R-HSA-9640194) ATP6V0C [tertiary granule membrane] (R-HSA-6800991) ATP6V0C [ficolin-1-rich granule membrane] (R-HSA-6800908) ATP6V0C [plasma membrane] (R-HSA-6806254) ATP6V0C [azurophil granule membrane] (R-HSA-6799363) ATP6V0C [phagocytic vesicle membrane] (R-HSA-1222603) ATP6V0C [endosome membrane] (R-HSA-912591)	0.666	4
UniProt:Q01453 PMP22	1	PMP22 [plasma membrane] (R-HSA-9615623)	0.556	3
UniProt:Q9H2L4 TMM60			0.556	3
UniProt:Q4LDR2 CTXN3			0.556	3
UniProt:Q9UBY5 LPAR3	1	LPAR3 [plasma membrane] (R-HSA-419379)	0.556	3
UniProt:P54849 EMP1			0.556	3
UniProt:Q5J8X5 M4A13			0.556	3
UniProt:Q69YG0 TMM42			0.556	3
UniProt:P56557 TM50B			0.556	3
UniProt:Q9NRP0 OSTC			0.556	3
UniProt:Q8TBU1 Q8TBU1			0.556	3
UniProt:Q9NVC3 S38A7			0.556	3
UniProt:Q6FHL7 Q6FHL7			0.556	3

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