Reactome | EDA [plasma membrane]

EDA [plasma membrane]

Stable Identifier

R-HSA-5667156

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Ectodysplasin-A, EDA_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q92838 EDA

Gene Names

EDA, ED1, EDA2

Chain

chain:1-391, chain:160-391

Reference Genes

COSMIC (genes):EDA EDA

dbSNP Gene:1896 EDA

ENSEMBL:ENSG00000158813 EDA

Participates

as a component of

EDA:EDAR [plasma membrane] (Homo sapiens)

as an input of

EDA binds EDAR (Homo sapiens)

Inferred To

EDA [plasma membrane] (Bos taurus)

EDA [plasma membrane] (Canis familiaris)

EDA [plasma membrane] (Gallus gallus)

EDA [plasma membrane] (Sus scrofa)

egr [plasma membrane] (Drosophila melanogaster)

Eda [plasma membrane] (Mus musculus)

Eda [plasma membrane] (Rattus norvegicus)

eda [plasma membrane] (Danio rerio)

eda [plasma membrane] (Xenopus tropicalis)

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P26678 PLN	2	p-S16-PLN [sarcoplasmic reticulum membrane] (R-HSA-5578813) PLN [sarcoplasmic reticulum membrane] (R-HSA-5490319)	0.886	11
UniProt:Q6P499 NIPAL3	1	NIPAL3 [plasma membrane] (R-HSA-5215974)	0.781	8
UniProt:Q96IW7 SEC22A	3	SEC22A [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688562) SEC22A [ER to Golgi transport vesicle membrane] (R-HSA-5688560) SEC22A [endoplasmic reticulum membrane] (R-HSA-5216111)	0.781	7
UniProt:P21145 MAL			0.781	7
UniProt:P54852 EMP3			0.781	7
UniProt:Q96F15 GIMA5			0.718	6
UniProt:P49447 CY561			0.718	6
UniProt:Q9UPQ8 DOLK	6	DOLK [endoplasmic reticulum membrane] (R-HSA-449274) DOLK M1I [endoplasmic reticulum membrane] (R-HSA-4755593) DOLK H408D [endoplasmic reticulum membrane] (R-HSA-4755548) DOLK C99S [endoplasmic reticulum membrane] (R-HSA-4755602) DOLK W304C [endoplasmic reticulum membrane] (R-HSA-4755557) DOLK Y441S [endoplasmic reticulum membrane] (R-HSA-4755590)	0.718	6
UniProt:O95214 LERL1			0.666	4
UniProt:P27449 ATP6V0C	7	ATP6V0C [endosome membrane] (R-HSA-912591) ATP6V0C [phagocytic vesicle membrane] (R-HSA-1222603) ATP6V0C [ficolin-1-rich granule membrane] (R-HSA-6800908) ATP6V0C [plasma membrane] (R-HSA-6806254) ATP6V0C [azurophil granule membrane] (R-HSA-6799363) ATP6V0C [tertiary granule membrane] (R-HSA-6800991) ATP6V0C [lysosomal membrane] (R-HSA-9640194)	0.666	4
UniProt:Q9H2L4 TMM60			0.556	3
UniProt:Q4LDR2 CTXN3			0.556	3
UniProt:Q9UBY5 LPAR3	1	LPAR3 [plasma membrane] (R-HSA-419379)	0.556	3
UniProt:P54849 EMP1			0.556	3
UniProt:Q5J8X5 M4A13			0.556	3
UniProt:Q69YG0 TMM42			0.556	3
UniProt:P56557 TM50B			0.556	3
UniProt:Q9NRP0 OSTC			0.556	3
UniProt:Q8TBU1 Q8TBU1			0.556	3
UniProt:Q9NVC3 S38A7			0.556	3
UniProt:Q6FHL7 Q6FHL7			0.556	3
UniProt:Q01453 PMP22	1	PMP22 [plasma membrane] (R-HSA-9615623)	0.556	3

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