K63polyUb-cIAP1,2 ubiquitinates TRAF3

Stable Identifier
Reaction [omitted]
Homo sapiens
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cIAP1,2 targets NIK for ubiquitination and degradation under unstimulated conditions but redirects its destructive action towards TRAF3 in response to receptor signals. K63polyUb-cIAP1,2 catalyses K48-linked polyubiquitination of TRAF3 leading to signal-induced TARF3 degradation.

Literature References
PubMed ID Title Journal Year
18997794 Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK

Mahoney, DJ, Wang, Y, Shiba, T, Mak, TW, Yeh, WC, Cheng, G, Dempsey, PW, He, J, Cheung, HH, Korneluk, RG, Yang, X, Zarnegar, BJ

Nat. Immunol. 2008
18997792 Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling

Zhang, W, Tseng, PH, Matsuzawa, A, Vignali, DA, Bergsagel, PL, Keats, JJ, Karin, M, Wang, H, Vallabhapurapu, S

Nat. Immunol. 2008
18635759 Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex

Zhang, W, Tseng, PH, Matsuzawa, A, Vignali, DA, Luo, JL, Gallagher, E, Karin, M, Wang, H, Vallabhapurapu, S

Science 2008
Catalyst Activity

ubiquitin-protein transferase activity of TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane]

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