NIK autophosphorylates on T559

Stable Identifier
R-HSA-5668545
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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NIK autophosphorylates on T559
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Signal-induced NIK accumulation and activation is likely an essential step for triggering the downstream signalling events in non-canonical NF-kB pathway. Like other MAP3Ks NIK may also be triggered by its phosphorylation. It has been suggested that threonine (T559) phosphorylation of NIK is required for its activity. T559 phosphorylation of NIK is likely mediated by autophosphorylation, which could be triggered through NIK accumulation (Lin et al. 1998).
Literature References
PubMed ID Title Journal Year
9742107 Molecular determinants of NF-kappaB-inducing kinase action

Geleziunas, R, Cunningham, ET, Greene, WC, Lin, X, Marcu, KB, Mu, Y

Mol. Cell. Biol. 1998
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Catalyst Activity

protein serine/threonine kinase activity of MAP3K14 [cytosol]

Physical Entity
MAP3K14 [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
NIK autophosphorylates on T559 (Bos taurus)
NIK autophosphorylates on T559 (Canis familiaris)
NIK autophosphorylates on T559 (Gallus gallus)
NIK autophosphorylates on T559 (Mus musculus)
NIK autophosphorylates on T559 (Rattus norvegicus)
NIK autophosphorylates on T559 (Saccharomyces cerevisiae)
NIK autophosphorylates on T559 (Sus scrofa)
NIK autophosphorylates on T559 (Xenopus tropicalis)
Authored
Garapati, P V  (2015-01-26)
Reviewed
Rajput, A  (2015-05-12)
Virgen-Slane, R  (2015-05-12)
Ware, CF  (2015-05-12)
Created
Garapati, P V  (2015-01-26)
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