Reactome | NOX1 complex:RAC1:GTP generates superoxide from oxygen

NOX1 complex:RAC1:GTP generates superoxide from oxygen

Stable Identifier

R-HSA-5668718

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane, extracellular region

ReviewStatus

5/5

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NOX1 complex:RAC1:GTP generates superoxide from oxygen

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The activity of the non-phagocytic NADPH oxidase 1 (NOX1) complex, composed of NOX1, NOXA1, NOXO1 and CYBA, is greatly enhanced upon RAC1:GTP binding, resulting in production of the superoxide O2- which can serve as a second messenger (Takeya et al. 2003, Miyano et al. 2006, Park et al. 2006, Cheng et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
16636067	Nox1-dependent reactive oxygen generation is regulated by Rac1 Cheng, G, Diebold, BA, Hughes, Y, Lambeth, JD	J. Biol. Chem.	2006
16329988	Molecular interaction of NADPH oxidase 1 with betaPix and Nox Organizer 1 Park, HS, Park, D, Bae, YS	Biochem. Biophys. Res. Commun.	2006
16762923	Direct involvement of the small GTPase Rac in activation of the superoxide-producing NADPH oxidase Nox1 Miyano, K, Ueno, N, Takeya, R, Sumimoto, H	J. Biol. Chem.	2006
12716910	Novel human homologues of p47phox and p67phox participate in activation of superoxide-producing NADPH oxidases Takeya, R, Ueno, N, Kami, K, Taura, M, Kohjima, M, Izaki, T, Nunoi, H, Sumimoto, H	J. Biol. Chem.	2003